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A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027)
RecruitingPhase 1Healthy volunteers welcome
An Open-Label, Single-Dose Clinical Study to Evaluate the Pharmacokinetics of Nemtabrutinib in Participants With Severe Renal Impairment
Who can join
Ages 18 to 80 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: The main inclusion criteria include but are not limited to the following: All participants: * Has a body mass index (BMI) ≥18.0 and ≤40.0 kg/m\^2 Participants with Severe Renal impairment (RI): * The participant has stable renal function as determined by historical measurements. Healthy volunteers: * Is medically healthy with no clinically significant medical history Exclusion Criteria: The main exclusion criteria include but are not limited to the following: Renal Impairment Participants: * History of any illness, other than renal impairment, that, in the opinion of the investigator, might confound the results of the study or poses an additional risk to the participant by their participation in the study. Healthy Matched Control Participants: * History of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases. Participants with a remote history of uncomplicated medical events (eg, uncomplicated kidney stones, as defined as spontaneous passage and no recurrence in the last 5 years, or childhood asthma) may be enrolled in the study at the discretion of the investigator
About the study
The purpose of this study is to learn what happens to nemtabrutinib in a person's body when given to participants with severe kidney disease and to healthy participants.
What is being tested
- Nemtabrutinib (drug)
Sponsor: Merck Sharp & Dohme LLC · Participants: 20 · Started: Sep 8, 2026
Contact the study team
- Toll Free Number · Phone: 1-888-577-8839
Official record on ClinicalTrials.gov — NCT07734610
Locations in the U.S.
| Florida | Floridian Clinical Research, LLC ( Site 0001), Miami Lakes |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.