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Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia

Recruiting

Evaluating Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia in Breast Cancer Survivors

Who can join

Ages 18 and older · Women

Full eligibility criteria
Inclusion Criteria:

-Individuals must meet all the following inclusion criteria in order to be eligible to participate in the study:

* Age ≥18 years
* Diagnosis of stage I-III hormone receptor-positive breast cancer
* Postmenopausal
* Currently receiving an aromatase inhibitor (anastrozole, letrozole, or exemestane) or within 5 years of initiation
* Report joint pain that started or worsened after initiation of AI therapy
* Report worst pain in the past week ≥3 on the BPI (0-10 scale)
* Able to complete study procedures in English
* Willing to be randomized to an intervention or attention control group and adhere to study procedures

Exclusion Criteria:

-An individual who meets any of the following criteria will be excluded from participation in this study:

* Undergoing active cancer treatment (excluding endocrine therapy)
* Uncontrolled cardiac or pulmonary disease that would limit safe participation
* Currently engaged in regular structured moderate- or vigorous-intensity exercise (e.g., brisk walking, jogging/running, cycling, swimming, aerobic classes, or resistance training) totaling ≥150 minutes per week over the past 3 months
* Currently participating in Tai Chi, yoga, Pilates, or other structured mind-body practice ≥2 times per week over the past 3 months
* Joint pain due to inflammatory arthritic conditions
* Recent surgery or joint injection within the past 4-6 weeks
* Initiation or dose change of corticosteroids or opioids within the past 4 weeks
* Planned discontinuation of AI therapy within the next 6 months
* This study is limited to women with breast cancer, as \<1% of cases occur in men and data on AIIA in male patients are limited

About the study

The objective of the pilot RCT is to evaluate the feasibility and acceptability of a Tai Chi intervention "TaiChi4Joint" vs. an HE AC group for relieving AIIA in women with hormone receptor positive stage I-III BCa. The investigators will pilot test our data collection for mechanism measures via three innovatively integrated biobehavioral pathways.

What is being tested

Sponsor: Thomas Jefferson University · Participants: 40 · Started: Jul 27, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07737951

Locations in the U.S.

PennsylvaniaSidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.