Home › Spinal Cord Injuries › NCT07739992

Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury

Dose-Optimization Study of Acute Intermittent Hypoxia (DOSA-SCI): Effects on Lower-Limb Motor Function and Physiological Responsiveness in Individuals With Incomplete Spinal Cord Injury

Who can join

Ages 18 to 75 · All sexes

Inclusion Criteria:

* Chronic Spinal Cord Injury (\>6 months)
* Motor incomplete SCI classified as AIS C or D
* Volitional ankle plantarflexion strength in at least one leg

Exclusion Criteria:

* Uncontrolled hypertension (outside 140/90 and 90/60)
* Concurrent medical illness
* Traumatic brain injury
* Cardiovascular complications
* Pulmonary complications
* Metabolic dysfunction
* Continued use of anti-spasticity medications
* Previously diagnosed obstructive sleep apnea

About the study

This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI). The objective is to identify the dose that most effectively improves motor output while also examining parameters that may account for variability in response.

What is being tested

• Sham AIH (other)
• Acute Intermittent Hypoxia (AIH) 15 (other)
• Acute Intermittent Hypoxia (AIH) 23 (other)

Sponsor: Milap Sandhu · Participants: 40 · Started: Jul 27, 2026

Contact the study team

• Milap Sandhu, PhD, PT · Phone: 312-238-6529

Official record on ClinicalTrials.gov — NCT07739992

Locations in the U.S.

Conditions

• Spinal Cord Injuries

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.