Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention

Inclusion Criteria:

1. Family history of SSD (defined as first-degree (e.g., a parent or a sibling), second-degree (e.g., an uncle or a grandparent), or other combinations of biological relatives in the family have or likely have a diagnosis of SSD or other closely related severe mental illnesses equivalent to at least 25% of genetic sharing) per medical record review and/or parent/legal guardian/self report and confirmed by a structured interview;
2. screening positive for two or more risk factors targeted by the intervention;
3. aged ≥ 9 and \<26 years of birthday;
4. Participants and parent(s)/legal guardian(s)/other family member(s) agree to participate;
5. psychiatrically stable and have no major changes in antidepressant, stimulant, or antipsychotic medication in the past 4 weeks.

Exclusion Criteria:

1. Current or past history of psychotic disorders or clinical high risk for psychosis (CHR-p) per study interview;
2. Current or past antipsychotic medication use to specifically treat a psychotic disorder;
3. major medical and neurological conditions;
4. moderate to severe intellectual disabilities or mild intellectual disabilities but expected to have difficulty completing the study assessments;
5. current drug or alcohol use that impacts functioning and study engagement;
6. Not able to give assent, permission, or consent;
7. Not able to undergo MRI.