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Pupillary Dilation Reflex in Healthy Volunteers

The Relationship Between Neurostimulation Intensity and Pupillary Dilation Reflex (PRD) in Healthy Volunteers

Who can join

Ages 18 to 60 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age 18-60 years.
* In good general health (self-reported).
* Able and willing to provide written informed consent.

Exclusion Criteria:

* Eye pathology that prevents accurate pupillometry.
* Pregnancy (Self-Report)
* Diagnosis of autoimmune disorders.
* Diagnosis of any neuropathic disorder
* Inability to complete questionnaires.

About the study

This a single site, observational study that will examine how the pupil responds to neurostimulation under different conditions in healthy adults. The objective is to measure pupillary dilation reflex (PRD) in response to increasing neurostimulation intensities using the AlgometRx device.

What is being tested

• No intervention (observational study) (other)

Sponsor: Children's National Research Institute · Participants: 60 · Started: Apr 29, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07746167

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.