Home › NCT07748832

Pneumococcal Carriage Duration

NIS103487 Duration of Streptococcus Pneumoniae Carriage in U.S. Children Under Five: A Pilot Longitudinal Study

Who can join

28 Days – 48 Months · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Are older than 28 days and under 4 years of age at the time of enrollment.
* Have a parent or legal guardian who:

  1. Provides written informed consent.
  2. Is able to read and speak English or Spanish.
  3. Agrees to comply with all study procedures, including completion of questionnaires and biweekly oropharyngeal (OP) swab collections from the child for a period of 12 months.

Exclusion Criteria:

* History of chronic medical conditions or immunocompromising conditions that may influence pneumococcal carriage or study participation, such as:
* cystic fibrosis
* cerebral palsy
* neuromuscular disorders
* congenital heart disease
* known congenital or acquired immunodeficiencies
* sickle cell disease
* undergoing immunosuppressive therapy (e.g., systemic corticosteroids ≥2 mg/kg/day for ≥14 days, chemotherapy, biologics)

About the study

Streptococcus pneumoniae (SPN) remains a leading cause of respiratory disease in young children despite widespread vaccination. Understanding the duration of pneumococcal carriage, patterns of co-colonization, and the influence of viral infections and the respiratory microbiome is essential to evaluate next-generation pneumococcal vaccines and inform public health strategies. Current data on Streptococcus pneumoniae carriage dynamics are limited in U.S. pediatric populations. This study aims to generate updated estimates of Streptococcus pneumoniae colonization and explore microbial interactions using high-resolution longitudinal sampling and genomic methods.

What is being tested

• Oropharyngeal (OP) swab (other)

Sponsor: University of Central Florida · Participants: 60 · Started: Jul 21, 2026

Contact the study team

• Dr. Amoy Fraser, PhD · Phone: 407-266-8742
• Aniya Barclay, MS · Phone: 407-266-8742

Official record on ClinicalTrials.gov — NCT07748832

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.