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Stroke Volume-based Fluid Resuscitation in AP
Recruiting
Stroke volUme-baSed Fluid resusciTAtIoN in AP (SUSTAIN)
Who can join
Ages 18 to 75 · All sexes
Full eligibility criteria
Inclusion Criteria: * Patients between the age of 18-75 * Predicted moderate and severe acute pancreatitis, which will be defined by the presence of SIRs, within 24 hours of enrollment Exclusion Criteria: * Patients with the inability to preform a straight leg raise (i.e amputation) * Patients with high risk of adverse event related to fluid resuscitation * NYHA Class \>= II Heart Failure * Child's B and C Cirrhosis * Dialysis Requirement * Clinical signs of hypervolemia, including pulmonary congestion (i.e dyspnea, pulmonary crackles on exam, interstitual edema on imaging) and ascites * Ages \<18 years old * Pregnant * Incarcerated * Unable to provide informed consent
About the study
The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.
What is being tested
- Lactated Ringer's (other)
- Lactated Ringers Stroke Volume Based Dosing (other)
Sponsor: University of Southern California · Participants: 80 · Started: Mar 19, 2026
Contact the study team
- James L Buxbaum, MD · Phone: 323 442 0876
- Jorge Zuniga-Gomez, BS · Phone: 323 442 0876
Official record on ClinicalTrials.gov — NCT07756476
Locations in the U.S.
| California | University of Southern California, Los Angeles |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.