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Photodynamic Therapy For Onychomycosis

Photodynamic Therapy For Onychomycosis: An Open Label Study

Who can join

Ages 18 to 100 · All sexes

Inclusion Criteria:

* Clinical and mycological diagnosis \[by potassium hydroxide (KOH) stain\] of onychomycosis

Exclusion Criteria:

* Known or suspected allergies or sensitivities to any components of any of the study drugs
* Patients with coagulation disorders
* Known or suspected claustrophobia
* Pregnancy during the treatment period
* Medically unable to consent
* Employees of the clinics
* Prisoners

About the study

The purpose of this study is clinical and mycological clearance of onychomycosis using photodynamic therapy (PDT) with aminolevulinic acid (ALA) 10% gel at 6 months, 3 months, 9 months and 12 months

What is being tested

• ALA 10% gel (drug)
• PDT (device)
• Urea (drug)

Sponsor: The University of Texas Health Science Center, Houston · Participants: 5 · Started: Aug 10, 2026

Contact the study team

• Stephen Tyring, MD, PhD, MBA · Phone: (281) 333-3376
• Luke Moore · Phone: (817) 795-7546

Official record on ClinicalTrials.gov — NCT07756671

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.