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Postoperative Tizanidine Use in Pelvic Reconstructive Surgery: A Pilot Study

Who can join

Ages 18 to 89 · Women

Inclusion Criteria:

* female, age ≥18 and ≤89 years old

  * any race/ethnicity
  * English and/or Spanish fluency
  * undergoing apical suspension:

    * sacrocolpopexy (laparoscopic or robotic)
    * uterosacral ligament suspension (vaginal, laparoscopic, or robotic)
    * sacrospinous ligament fixation
    * iliococcygeus suspension
  * surgery being performed at Hartford Hospital

Exclusion Criteria:

* male

  * age \<18 or ≥90 years old
  * pregnant
  * breastfeeding
  * documented diagnosis of hypotension in EMR problem list, BP in office or at pre-op PAC (confirmed on repeat) to be systolic \<100 mm Hg and/or diastolic \<70 mm Hg
  * known intolerance or sensitivity to tizanidine
  * current use of:

    * CYP1A2 inhibitor:
    * clonidine (alpha-2 agonist) antihypertensive
    * opioid
    * muscle relaxant
  * pre-existing

    * hepatic impairment as defined as transaminitis with ALT or AST \>2x upper limit of normal
    * diagnoses of cirrhosis, alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD)
    * renal impairment as defined by creatinine clearance \<25 mL/min
  * obstructive sleep apnea
  * non-English or non-Spanish speaking
  * past opioid dependence
  * concurrent diagnosis of malignancy
  * concurrent surgery apart from pelvic reconstructive surgery with another specialty
  * unable/unwilling to consent to participate

About the study

The goal of this clinical trial is to evaluate whether adding tizanidine to the standard postoperative pain regimen improves recovery after pelvic reconstructive surgery in adult women. The main questions it aims to answer are:

Does postoperative tizanidine improve patient-reported recovery 4-6 weeks after surgery? Does tizanidine reduce postoperative pain, opioid use, constipation, and healthcare utilization while improving functional recovery?

Researchers will compare standard postoperative care plus tizanidine with standard postoperative care alone to determine whether tizanidine improves postoperative recovery.

Participants will:

* Be randomly assigned to receive either standard postoperative pain management alone or standard postoperative pain management plus tizanidine for 2 weeks after surgery. * Complete electronic surveys before surgery, 1-2 days after surgery, 2 weeks after surgery, and 4-6 weeks after surgery to assess pain, recovery, activity, and bowel function. * Allow researchers to review information from their electronic medical record, including healthcare utilization and postoperative outcomes, during the 4-6 weeks following surgery.

What is being tested

• Tizanidine (drug)
• Standard-of-Care Therapy (other)

Sponsor: Hartford Hospital · Participants: 186 · Started: Aug 21, 2026

Contact the study team

• Sindhura Vallabhaneni, MD · Phone: (860) 972-4338

Official record on ClinicalTrials.gov — NCT07766837

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.