Home › NCT07772869

Uterine Lavage to Detect Ovarian Cancer Risk

Collection of Uterine Lavage in High-Risk Patients as a Potential Biomarker for Ovarian Cancer Risk

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* \> 18 years of age
* Have a pathogenic BRCA1 or BRCA2 germline variant
* Planned risk-reduction surgery
* Presence of uterus and at least one fallopian tube

Exclusion Criteria:

* Prior tubal ligation
* Prior history of known ovarian or endometrial cancer

About the study

This clinical trial develops a non-surgical approach using uterine lavage samples to screen for progression to ovarian cancer in high-risk patients carrying BRCA mutations. Women with inherited mutations in the BRCA1 and BRCA2 genes (BRCA carriers) have a much higher lifetime risk of developing ovarian cancer. Currently there are no effective ovarian cancer screening or early detection tests for BRCA carriers. Uterine lavage is a procedure that uses saline to rinse and collect cells from the fallopian tube. Molecular analysis of these samples may help proactively detect genetic alterations that are indicative of progression to ovarian cancer in women with BRCA mutations.

What is being tested

• Uterine Lavage (other)
• Archive Sample (procedure)
• Survey Administration (other)

Sponsor: University of Washington · Participants: 75 · Started: Sep 3, 2026

Contact the study team

• Intake Coordinators · Phone: 206-616-3913
• Intake Coordinators · Phone: 206-616-2532

Official record on ClinicalTrials.gov — NCT07772869

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.