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Tear Fluid for the Detection of Tumor-associated Extracellular Vesicles in Glioblastoma Patients
Molecular Analysis of Tear Fluid Collected From Glioblastoma Patients: A Two-Phased Pilot Study
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Adults (age ≥ 18) * Male and female * All racial and ethnic groups * Pathologically-proven diagnosis of GBM or healthy volunteers * For GBM patients, presence of a previously placed Rickham reservoir or shunt * Able to provide informed consent (or via legal representative) * Willing to undergo Schirmer strip procedure Exclusion Criteria: * Active ocular infection or inflammation * Recent ocular surgery (within 3 months) * Chronic dry eyes * Known allergy or hypersensitivity to topical anesthetics * Cognitive impairment * Pregnancy * Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with study procedures or place the participant at undue risk
About the study
This clinical trial tests the impact of tear fluid in detecting tumor-associated extracellular vesicles (TEVs) in patients with glioblastoma. Brain tumors release small particles, called TEVs, that may provide information about the tumor, including how it responds to treatment. These particles can be found in cerebrospinal fluid (CSF), which is the fluid that surrounds the brain and spinal cord. Collecting CSF can be difficult and expensive, especially if samples are needed frequently to track these particles over time. Tear fluid is easier to collect than spinal fluid. If tears are found to contain similar tumor-related particles, changes in the tumor may be tracked by studying the particles found in tear fluid.
What is being tested
- Biospecimen Collection (procedure)
- Biospecimen Collection (procedure)
- Electronic Health Record Review (other)
- Questionnaire Administration (other)
Sponsor: City of Hope Medical Center · Participants: 30 · Started: Oct 23, 2026
Contact the study team
Official record on ClinicalTrials.gov — NCT07775534
Locations in the U.S.
| California | City of Hope Medical Center, Duarte |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.