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Metatranscriptomic Markers of Colonic Neoplasia

Metatranscriptomic Markers As A Predictor of Colonic Neoplasia at the Time of Colonoscopy

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Male or female, aged 18 years or older
* Undergoing colonoscopy with bowel preparation
* Able to provide stool and saliva samples prior to colonoscopy
* No stoma present
* No known personal history of colorectal cancer

Exclusion Criteria:

* Individuals under 18 years of age
* Patients with a stoma
* Personal history of colorectal cancer

About the study

This study is a collaboration between Viome Life Sciences and Scripps Research Institute to develop and validate a noninvasive molecular diagnostic test for the detection of colorectal polyps. Approximately 1,000 participants undergoing colonoscopy will provide saliva and stool samples prior to their procedure. Molecular features identified in these samples will be evaluated in relation to colonoscopy findings to develop a predictive model for colorectal polyp detection. The resulting model will then be evaluated in an independent validation dataset to assess its performance for identifying individuals with colorectal polyps.

What is being tested

• This is an observational study that has no interventions (other)

Sponsor: Viome · Participants: 1,000 · Started: Dec 20, 2025

Contact the study team

• Momchilo Vuyisich, PhD · Phone: 855-958-4663

Official record on ClinicalTrials.gov — NCT07786818

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.