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Repeat Biliary Point of Care Ultrasound for Detecting Early Acute Cholecystitis

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* ≥ 18 years of age
* Presenting to the emergency department with abdominal pain with clinical concern for possible acute cholecystitis
* Initial biliary US interpreted as normal, equivocal or negative for acute cholecystitis
* 2-6 hours since initial biliary ultrasound with ongoing symptoms
* General surgery consult placed or additional non-ultrasound advanced imaging ordered
* Fluency in English or Spanish

Exclusion Criteria:

* \< 18 years of age
* \> 6 hours since initial biliary US
* Asymptomatic/resolved symptoms or pending discharge from the emergency department
* Initial ultrasound positive for acute cholecystitis or other findings to explain presenting symptoms
* Baseline ascites
* Prior cholecystectomy
* Unable or unwilling to provide consent
* Presenting to a facility other than study site emergency department
* Transferred patients from outside facilities

About the study

The goal of this interventional, prospective study is to determine the clinical utility of a repeat point-of-care ultrasound of the gallbladder in adult emergency department patients with abdominal pain for which initial imaging is not diagnostic. The main question it aims to answer is: Does a repeat ultrasound improve early identification of gallbladder inflammation?

Participants will undergo a repeat ultrasound of the gallbladder while still in the emergency department and will be followed up to determine subsequent diagnoses, disposition, consultations and other clinical information.

What is being tested

• Repeat biliary point of care ultrasound (diagnostic test)

Sponsor: WellSpan Health · Participants: 90 · Started: Jun 1, 2026

Contact the study team

• Brent Becker Principal Investigator, MD · Phone: 717-851-4819
• Kristen Wilhelm Research Coordinator, MS · Phone: 717-812-5075

Official record on ClinicalTrials.gov — NCT07792200

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.