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A Study of RO7890597 in Healthy Adult Volunteers
A Phase I Study to Evaluate the Safety and Pharmacokinetics of RO7890597 Following Single and Multiple Ascending Doses, and the Effects of Food, Proton-Pump Inhibition, And CYP3A Inhibition in Healthy Adult Volunteers
Who can join
Ages 18 to 65 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Agreement to adhere to the contraception requirements. * Body mass index of 18 to 30 kilograms per square meter (kg/m²). Exclusion Criteria: * Pregnant, breastfeeding, or intending to become pregnant during the study or required contraception period. * Treatment with investigational biologic therapy within 90 days or 5 elimination half-lives, whichever is longer, before study drug initiation. * Treatment with investigational non-biologic therapy within 28 days or 5 elimination half-lives, whichever is longer, before study drug initiation. * Treatment with immunosuppressive medication within 28 days or 5 elimination half-lives, whichever is longer, before study drug initiation. * Treatment with any vaccine within 14 days prior to initiation of study drug, or within 28 days for a live or live attenuated vaccine. * Poor peripheral venous access. * Major surgery within 28 days before study drug initiation or planned major surgery during the study. * Current infection or recent infection requiring antibiotics as defined in the protocol. * History of malignancy within 5 years before screening, except for specified adequately treated cancers. * History of clinically significant drug or food allergy.
About the study
This study will evaluate the safety, pharmacokinetics (PK), and activity of single and multiple doses of RO7890597 compared with placebo in healthy volunteers. The study includes single ascending dose (SAD) stage, multiple ascending dose (MAD) stage, food-effect and proton pump inhibitor (PPI) stages, and a supplemental drug-drug interaction (DDI) stage.
What is being tested
- RO7890597 (drug)
- Placebo (drug)
- Rabeprazole (drug)
- Itraconazole (drug)
Sponsor: Genentech, Inc. · Participants: 139 · Started: Aug 28, 2026
Contact the study team
- Reference Study ID Number: GA46708 https://forpatients.roche.com/ No attachments to email below. · Phone: 888-662-6728 (U.S. and Canada)
Official record on ClinicalTrials.gov — NCT07797478
Locations in the U.S.
| Kansas | ICON (LPRA) - Lenexa, Lenexa |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.