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Plastic Detox During IVF Treatment
Endocrine Disrupting Chemical Detox: a Practical Method to Decrease Environmental Exposures and an Evaluation of the Impact on in Vitro Fertilization Treatment
Who can join
Ages 18 to 45 · All sexes
Full eligibility criteria
Inclusion criteria: \- Unexplained infertility diagnosis (no identifiable male or female causes to infertility) Exclusion criteria: * Female age 38 years and older * Male age 45 and older * Diagnosis of diminished ovarian reserve * Diagnosis of PCOS/PMOS * Smoking or drug use in either male and/or female partner * BMI \>40 in either partner * Patients using donor oocytes/donor sperm/donor embryos
About the study
Environmental pollutants are present in many aspects of everyday life. Exposures to common household products, such as food packaging and cookware, may affect reproductive health. Many of these environmental toxicants are known as "endocrine disrupting chemicals" because they can interfere with the body's hormone systems. Our study aims to create a guide that explains common sources of environmental toxicants and offer practical steps to reduce exposure. The investigators will evaluate how well participants understand this information and how consistently the intervention is maintained over time.
To assess whether these changes reduce environmental pollutant exposure, the investigators will measure levels of two classes of toxicants within the urine and blood at the beginning, middle and end of the study in patients struggling with infertility that are planning in vitro fertilization (IVF) treatment. The investigators will also measure the same chemicals in follicular fluid (fluid which surrounds developing eggs in the ovary) and seminal fluid (fluid which surrounds the sperm in semen) and compare these levels to samples from similar patients who did not receive the education or make environmental changes. The goal of this project is to determine whether simple changes to reduce exposure to environmental pollutants can lower chemical levels of toxicants in the body and whether this may ultimately impact outcomes for patients undergoing in vitro fertilization.
What is being tested
- Environmental Pollutant Detox (behavioral)
Sponsor: Abigail Mancuso · Participants: 60 · Started: Oct 26, 2026
Contact the study team
- Abigail Mancuso, MD · Phone: 319-356-1767
Official record on ClinicalTrials.gov — NCT07802691
Locations in the U.S.
| Iowa | University of Iowa, Iowa City |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.