🔎 Trials Near Me

Home › Ovarian Cancer › NCT07816666

Torvutatug Samrotecan With or Without Bevacizumab as Maintenance Treatment of Platinum-sensitive Relapsed Epithelial Ovarian Cancer

RecruitingPhase 3

A Randomised, Open-label, Phase III Study of Torvutatug Samrotecan With or Without Bevacizumab Versus Standard of Care as Second- or Third-Line Maintenance Treatment in Participants With Platinum-sensitive Relapsed Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (TREVI-OC-03)

Who can join

Ages 18 and older · Women

Full eligibility criteria
Inclusion Criteria:

* Participants with confirmed histology of high-grade epithelial serous or endometrioid ovarian, fallopian tube, or primary peritoneal cancer.
* Provision of an archival FFPE tumour sample
* Participants who received at least one, and no more than 2 lines of prior systemic anticancer therapy.
* Participants with radiologically confirmed disease relapse ≥ 6 months after their last platinum chemotherapy infusion in the previous line of treatment
* Participants who received 4-6 cycles of PBC during the induction phase of their current line of treatment.
* Participants assigned to bevacizumab must have received a minimum of 3 cycles of bevacizumab with 3 cycles of PBC prior to randomisation.
* Participants with non-progressive disease upon completion of PBC in their current line of treatment.
* Participants with documented BRCA mutation 1/2 must have received prior PARP inhibitor (unless ineligible due to contraindications, precautions, or intolerance).

Exclusion Criteria:

* Participants with tumours of non-epithelial origin, borderline tumours, clear cell OC, mucinous OC, carcinosarcoma, or low-grade epithelial tumours.
* Participants with history of (non-infectious) ILD/pneumonitis that required steroids, or supplemental oxygen, or has current ILD/pneumonitis, or where suspected ILD/pneumonitis cannot be ruled out by imaging at Screening
* Participants with non-healing wound, active ulcer, or bone fracture (not applicable if not receiving bevacizumab)
* Participants with evidence of active or ongoing bowel obstruction (not applicable if not receiving bevacizumab)
* Participants with prior exposure to any FRα-targeted therapy, including MIRV, or any TOP1i Antibody-drug Conjugate (ADC)

About the study

The purpose of this study is to measure the efficacy and safety of torvutatug samrotecan (torvu-sam) with or without bevacizumab compared to standard of care (SoC) as maintenance treatment in participants with platinum-sensitive relapsed ovarian cancer (PSR OC)

What is being tested

Sponsor: AstraZeneca · Participants: 600 · Started: Sep 24, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07816666

Locations in the U.S.

AlaskaResearch Site, Anchorage (Not yet recruiting)
FloridaResearch Site, Miami (Not yet recruiting)
IndianaResearch Site, Indianapolis (Not yet recruiting)
LouisianaResearch Site, Shreveport (Not yet recruiting)
MarylandResearch Site, Columbia (Not yet recruiting)
MichiganResearch Site, Ann Arbor (Not yet recruiting)
Research Site, Detroit (Not yet recruiting)
New YorkResearch Site, Albany (Not yet recruiting)
Research Site, Buffalo (Not yet recruiting)
Research Site, New York (Not yet recruiting)
Research Site, New York (Not yet recruiting)
OhioResearch Site, Cleveland (Not yet recruiting)
Research Site, Cleveland (Not yet recruiting)
Research Site, Mayfield Heights (Not yet recruiting)
PennsylvaniaResearch Site, Philadelphia (Not yet recruiting)
Research Site, Willow Grove (Not yet recruiting)
TexasResearch Site, Houston (Not yet recruiting)
UtahResearch Site, Salt Lake City (Not yet recruiting)
VirginiaResearch Site, Norfolk (Not yet recruiting)
West VirginiaResearch Site, Morgantown (Not yet recruiting)

Conditions

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.