Development of a Noninvasive Metric to Measure Small Bowel Sensation - The Small Intestine Stress Test

Inclusion Criteria:

* No current gastrointestinal symptoms
* No prior history of GI disorders, in particular DGBIs
* Ability to provide informed consent
* Ability to participate in study procedures
* Absence of other diseases (structural or metabolic) which could interfere with interpretation of the study results
* For females, must not be pregnant or lactating due to radiation exposure.
* Stable doses of thyroid replacement, estrogen replacement, low-dose aspirin for cardioprotection, and birth control are permissible.

Exclusion Criteria

* Subjects on any medications that impact transit or integrity of small bowel mucosal barrier (e.g. chronic NSAIDS) of the GI tract will be excluded.
* Patients with prior bowel surgery (not including appendectomy and cholecystectomy)
* Patients who may have altered sensation (central sensitization or conditions that may induce bowel hyperalgesia) based on PI review of medical history (ie, fibromyalgia, endometriosis, chronic pelvic pain)