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Lower Body Negative Pressure to Validate Physiological Monitors

Who can join

Ages 18 to 55 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Non-obese (BMI\<30)
* Non-smokers
* Free of any systemic diseases including hypertension, diabetes, coronary artery disease, neurologic disease, or any other major medical co-morbidity.
* Women will be either surgically sterilized or non-pregnant as determined by a urine pregnancy test (within 48 hours of the study day)

Exclusion Criteria:

* Individuals taking GLP-1 medications or compounds known to affect responses of the autonomic nervous system to orthostatic stress (e.g., β-blockers)
* Pregnant women

About the study

The purpose of this research is to test the accuracy of non-invasive physiological monitors while the body responds to different levels of lower body negative pressure (LBNP).

What is being tested

• Lower Body Negative Pressure with Noninvasive Physiological Monitoring (diagnostic test)

Sponsor: Mayo Clinic · Participants: 50 · Started: Sep 30, 2026

Contact the study team

• Pamela Engrav · Phone: 507-255-6938
• Ronee Harvey · Phone: 507-255-1466

Official record on ClinicalTrials.gov — NCT07840144

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.