Home › Venous Thromboembolism › NCT07856641
Circadian Variation of Anti-Factor Xa in Hospitalized Trauma Patients
RecruitingObservational study
Who can join
Ages 18 to 80 · All sexes
Full eligibility criteria
Inclusion Criteria: * Inpatient admission for acute traumatic injury ≥72 hours * Prescribed LMWH subcutaneous for VTE chemoprophylaxis Exclusion Criteria: * Pregnancy * Brain hemorrhage or non-survivable injury * Chronic Kidney disease ≥ 3b estimated Glomerular Filtration Rate (eGFR) less than 30 interferes with coagulation * Chronic liver failure •-Acute stimulant use of cocaine and methamphetamine * Active VTE or ongoing anticoagulation at admission * History of coagulopathy or inherited bleeding disorders * Chronic alcohol as defined as a documented diagnosis of alcohol use disorder or alcohol consumption exceeding established risk thresholds (men \>14 drinks/week; women \>7 drinks/week) within the prior 3-6 months * Unmanaged psychiatric conditions as defined as diagnosed psychiatric disorder with evidence of inadequate or no active treatment or documented poor symptom control * Neurologic injury involving hypothalamic or circadian regulatory centers
About the study
The purpose of this study is to determine whether a circadian rhythm exists in anti-FXa levels and AT3 activity in hospitalized trauma patients receiving low-molecular-weight heparin (LMWH) chemoprophylaxis
Sponsor: The University of Texas Health Science Center, Houston · Participants: 40 · Started: Aug 26, 2026
Contact the study team
- Evaline W Kihara, MSN, APRN, AGACNP-BC, CCRN · Phone: (713) 500-6362
- Nikhil Padhye, PhD · Phone: (713) 500-2035
Official record on ClinicalTrials.gov — NCT07856641
Locations in the U.S.
| Texas | HCA Houston Northwest Medical Center, Houston |
Conditions
From ClinicalTrials.gov, data retrieved Oct 3, 2026. Each study sets its own eligibility; the study team decides who can join.