Feasibility and Acceptability of Remote Saliva Collection

Inclusion Criteria:

SURVIVORS

* The survivor is a childhood survivor of Acute Lymphocytic Leukemia (ALL).
* The survivor was treated on one of the following St. Jude Total Therapy Studies:

  1. TOTAL Therapy study XVI for Newly Diagnosed Patients with ALL (TOTXVI) OR
  2. Total Therapy for Children with Acute Lymphoblastic Leukemia and Lymphoma (TOT17)
* The survivor is cancer-free.
* The survivor is at least 5 years out from the ALL diagnosis.
* The survivor is at least 2 years out from completion of treatment.
* The survivor did not receive cranial therapy as part of ALL therapy.
* The survivor is aged ≥8 to 18 years old at the time of enrollment.
* The survivor has completed their After Completion of Therapy (ACT) clinic consultation.
* The survivor is able to speak and read English.
* The survivor has internet access.

SIBLINGS

* The sibling has a brother or sister who is an ALL survivor participating in this study.
* The sibling is aged ≥8 to18 years old at the time of enrollment.
* The sibling is able to speak and read English.
* The sibling has internet access.

CAREGIVERS

* The caregiver provides primary care or support to an ALL survivor that is in this study.
* The caregiver resides in the home full-time with enrolled survivor and sibling.
* The caregiver is able to speak and read English.
* The caregiver has internet access.
* The caregiver is willing and able to assist with at home biospecimen collection.

Exclusion Criteria:

SURVIVORS and SIBLINGS

* Survivor and/or sibling has a diagnosis of Down's Syndrome.
* Survivor and/or sibling has a diagnosis of autism spectrum disorder.
* Survivor and/or sibling has a diagnosis of another pervasive developmental disorder not listed above.
* Survivor and/or sibling has a history of prolonged treatment with steroid medications or systemic glucocorticoids for reasons other than ALL.
* Survivor and/or sibling resides outside of the United States.
* Inability or unwillingness of survivor and/or sibling and/or legal guardian/representative to give written informed consent.

CAREGIVERS Note: There are no exclusion criteria for caregivers.