Home › Sudden Cardiac Arrest › NCT07890610
Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest
Who can join
37 Weeks – 18 Years · All sexes
Full eligibility criteria
Inclusion Criteria: * Arrest in an ICU * Patients received chest compressions for at least 1 minute Exclusion Criteria: * Lack of commitment to aggressive therapies (e.g., CPR performed as part of end-of-life care) * Brain death determination prior to CPR * Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes) * Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR
About the study
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital cardiac arrest (IHCA). In addition, the investigators will determine optimal epinephrine dosing strategies based on the initial physiologic response to epinephrine, and to develop machine learning (ML) algorithms to guide intra-arrest therapy.
Sponsor: Children's Hospital of Philadelphia · Participants: 1,620 · Started: Jul 1, 2024
Contact the study team
- Jessica Goldstein · Phone: 215-590-1859
- CHOP RSC Clinical Research Program Manager · Phone: 215-590-1859
Official record on ClinicalTrials.gov — NCT07890610
Locations in the U.S.
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.