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Pharmacokinetic (PK) Study of Phytochemicals in Whole Grains (WGs)- Brown Rice

Who can join

Ages 25 to 70 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Adults aged 25-70 years
* Body mass index (BMI) between 18 and 30 kg/m²
* Able to read, speak, and understand English
* No known allergy or intolerance to the test foods
* Normal blood and urine biochemical parameters
* No antibiotic use within the past 6 months
* Willing and able to comply with all study procedures, including dietary restrictions throughout the study period
* No medical conditions or lifestyle factors that, in the opinion of the investigators, would interfere with the study objectives

Exclusion Criteria:

* Active disease, including gout, heart disease, peripheral vascular disease, kidney disease, liver disease, cancer, diabetes, gastrointestinal disorders, or endocrine disorders that may interfere with the study
* Current smoker or use of tobacco products
* Unwilling or unable to comply with the required dietary restrictions during the study period

About the study

The purpose of this research study is to identify biomarkers (measurable signs).

in the body like substances in blood or urine) of whole-grain (WG) brown rice intake following an acute exposure in a pharmacokinetic (how the body absorbs, processes, and gets rid of a substance or ingredient) feeding study. In this aim, investigators will conduct a randomized crossover acute pharmacokinetic study of brown rice. Investigators will then use a targeted metabolomics approach to identify the exposure markers of brown rice intake, further develop analytical methods to study its pharmacokinetics, build an in-house WG metabolite database, and use an untargeted metabolomics approach to investigate postprandial biomarkers of brown rice intake. At the completion of this study, the expectation is that investigators will identify brown rice phytochemicals and its metabolites as objective biomarkers of total and individual WGs that are commonly consumed by Americans.

What is being tested

• Whole-Grain Brown Rice (dietary supplement)
• Refined White Rice (dietary supplement)

Sponsor: North Carolina Agriculture & Technical State University · Participants: 16 · Started: Jan 15, 2027

Contact the study team

• Shengmin Sang · Phone: 704-250-5710

Official record on ClinicalTrials.gov — NCT07898137

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.