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Decision Support for Chemoprevention

Recruiting

Integrating Breast Cancer and Cardiovascular Disease Risk to Explore Decision-Making for Chemoprevention Among Women at High Risk for Breast Cancer

Who can join

Ages 40 to 79 · Women

Full eligibility criteria
Inclusion Criteria:

1. Women, age 40-79 years (ages which overlap for the BCSC and ASCVD risk calculators)
2. High-risk for breast cancer based upon any of the following criteria:

   * Histologically-confirmed atypical hyperplasia or lobular carcinoma in situ
   * At least a 3% breast cancer risk at 5 years or 5% risk at 10 years or 20% lifetime risk according to one of the following breast cancer risk models: Breast Cancer Surveillance Consortium risk calculator V3 (https://tools.bcsc-scc.ucdavis.edu/BC5yearRisk/#calculator), Gail Breast Cancer Risk Assessment Tool (https://bcrisktool.cancer.gov/calculator.html), Tyrer-Cuzick model V8 (https://ibis-risk-calculator.magview.com), or BOADICEA canrisk model (https://www.canrisk.org)
   * Known carriers of germline pathogenic/likely pathogenic variant in the following breast cancer predisposition genes (ATM, BRCA2, CHEK2, or PALB2)
   * Prior chest wall irradiation before age 30 years
3. English- or Spanish-speaking
4. Has a clinician affiliated with NYP/CUIMC
5. Able to provide written, verbal or online informed consent

Exclusion Criteria:

* Patients who have a prior history of invasive breast cancer or ductal carcinoma in situ are ineligible to participate.

About the study

The purpose of this study is to find out whether electronic tools that provide information and reminders to people at high risk for breast cancer and their healthcare providers can increase the use of medications, such as tamoxifen, that may help lower the risk of developing breast cancer. The study will also look at how these tools can be successfully used as part of routine medical care.

What is being tested

Sponsor: Columbia University · Participants: 240 · Started: Oct 7, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07899151

Locations in the U.S.

New YorkColumbia University Irving Medical Center, New York

Conditions

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.