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Decision Support for Chemoprevention
Integrating Breast Cancer and Cardiovascular Disease Risk to Explore Decision-Making for Chemoprevention Among Women at High Risk for Breast Cancer
Who can join
Ages 40 to 79 · Women
Full eligibility criteria
Inclusion Criteria: 1. Women, age 40-79 years (ages which overlap for the BCSC and ASCVD risk calculators) 2. High-risk for breast cancer based upon any of the following criteria: * Histologically-confirmed atypical hyperplasia or lobular carcinoma in situ * At least a 3% breast cancer risk at 5 years or 5% risk at 10 years or 20% lifetime risk according to one of the following breast cancer risk models: Breast Cancer Surveillance Consortium risk calculator V3 (https://tools.bcsc-scc.ucdavis.edu/BC5yearRisk/#calculator), Gail Breast Cancer Risk Assessment Tool (https://bcrisktool.cancer.gov/calculator.html), Tyrer-Cuzick model V8 (https://ibis-risk-calculator.magview.com), or BOADICEA canrisk model (https://www.canrisk.org) * Known carriers of germline pathogenic/likely pathogenic variant in the following breast cancer predisposition genes (ATM, BRCA2, CHEK2, or PALB2) * Prior chest wall irradiation before age 30 years 3. English- or Spanish-speaking 4. Has a clinician affiliated with NYP/CUIMC 5. Able to provide written, verbal or online informed consent Exclusion Criteria: * Patients who have a prior history of invasive breast cancer or ductal carcinoma in situ are ineligible to participate.
About the study
The purpose of this study is to find out whether electronic tools that provide information and reminders to people at high risk for breast cancer and their healthcare providers can increase the use of medications, such as tamoxifen, that may help lower the risk of developing breast cancer. The study will also look at how these tools can be successfully used as part of routine medical care.
What is being tested
- RealRisks Decision Aid (behavioral)
Sponsor: Columbia University · Participants: 240 · Started: Oct 7, 2026
Contact the study team
- Research Nurse Navigator · Phone: 212-342-5162
- Rita Kukafka, DrPH, MA · Phone: 212-305-1945
Official record on ClinicalTrials.gov — NCT07899151
Locations in the U.S.
| New York | Columbia University Irving Medical Center, New York |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.