A Study of 68Ga-FAPI Breast PET/MRI Scans in People With Breast Cancer

Inclusion Criteria:

* Age ≥ 18
* ECOG Performance Status of ≤ 2
* Ability to review and signed informed consent
* Histologically confirmed, newly diagnosed invasive breast cancer
* Lymph node metastases (either histologically confirmed or radiographic evidence of lymph node metastases).
* Planned to undergo SOC NAC prior to surgical resection as outlined in section 4.1

Exclusion Criteria:

* Pregnancy or lactation.
* Patients who cannot undergo PET/MRI scanning because of:

  * devices or implants that are not MRI safe
  * hypersensitivity or known allergy to gadolinium-based contrast agents
  * physical fitness not allowing scanning in prone for 30 minutes
  * weight limits (450 lb. weight limit)
* Severe kidney disfunction (estimated GFR \< 30 ml/min/1.73 m2) (CKD-EPI (2021))
* Imaging features suspicious for concomitant in-situ cancer (LCIS/DCIS), such as nonbiopsied groups of microcalcifications
* Distant metastases (contraindication for NAC)