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PM2.5 Exposure, Obesity, and Cardiovascular Health

Investigating Interactions Between PM2.5 Exposure, Obesity, Cardiovascular Health and Dietary Antioxidant in Subjects With Obesity

Who can join

Ages 21 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* ≥21 years old
* diagnosis of hypertension (BP ≥140/90 mm Hg)
* obesity (BMI\>30)

Exclusion Criteria:

* any CV event (myocardial infarction, stroke, heart failure) in the past 3 months
* unstable CV condition (class 3-4 angina or heart failure) or any medical condition that would place the subject at risk from participation or jeopardize study integrity (per investigators)
* expected overnight travel outside their home during the 9-week study period
* unable to comprehend/sign informed consent
* lung disease requiring oxygen
* cancer receiving active treatment or chemotherapy
* CPAP use for sleep apnea
* CV medication change in the prior month

About the study

Obesity and exposure to fine particulate matter (particles of aerodynamic diameter less than 2.5 µm, PM2.5) air pollution are established risk factors for cardiovascular (CV) morbidity and mortality. This proposed pilot project seeks to assess interactions between PM2.5 exposure, obesity, CV health, and dietary antioxidant in subjects with obesity.

What is being tested

• Air filtration systems without filters (sham) (device)

Sponsor: Michigan State University · Participants: 20 · Started: Jun 18, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07924839

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.