Home › Aphasia › NCT07926347

Functional Reorganization and Recovery of the Language and Domain-general Multiple Demand Systems in Aphasia

Who can join

Ages 18 to 80 · All sexes

Inclusion Criteria:

* at least 12 weeks post-stroke at time of study enrolment
* medically and neurologically stable (no active seizures for 6 months) and at least wheelchair ambulatory
* premorbid fluency in English
* a family member or caregiver available to assist in study setup and in communicating with study staff

Exclusion Criteria:

* a major, active neurological condition other than stroke, as determined by medical record review
* history of cognitive impairment unrelated to stroke, such as dementia
* history of symptomatic stroke prior to index stroke
* severe uncorrected vision and/or hearing problems likely to impact study participation
* comorbid learning or language disorder diagnosed prior to stroke or as a child

About the study

The objective of this study is to apply state-of-the art brain imaging approaches to evaluate new hypotheses about the contributions of core linguistic vs. domain-general executive systems to language processing and recovery in patients with varying degrees of linguistic impairment. Specifically, the investigators will first characterize the degree to which standard language assessments tax the domain-general Multiple Demand (MD) network (Aim 1). And then systematically investigate the causal contributions of the language and the MD networks to language processing and aphasia recovery in patients of varying severity (Aims 2 and 3).

What is being tested

• Constant Therapy program (behavioral)

Sponsor: Boston University Charles River Campus · Participants: 100 · Started: 2026-12

Contact the study team

• Swathi Kiran, PhD · Phone: 617-358-5478

Official record on ClinicalTrials.gov — NCT07926347

Locations in the U.S.

Conditions

• Aphasia

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.