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Patent Foramen Ovale clinical trials recruiting in the U.S.
7 studies for Patent Foramen Ovale are recruiting participants at sites across the United States.
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Recently updated studies
Abbott Structural Heart Device Registry
RecruitingObservational study
All ages · All sexes · Updated Sep 1, 2026 · NCT06590467GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
Recruiting
Ages 18 to 70 · All sexes · Updated Jul 30, 2026 · NCT03821129Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO Study
Recruiting
Ages 18 to 65 · All sexes · Updated Jul 27, 2026 · NCT07172464Pulmonary Embolism and Right-to-Left Shunts
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT07519876NobleStitch EL STITCH Trial is a PFO Comparative Trial
Recruiting
Ages 18 to 60 · All sexes · Updated Mar 23, 2026 · NCT04339699Non-Invasive Detection of Right-to-Left Cardiac Shunts
RecruitingObservational study
Ages 18 and older · All sexes · Updated Feb 19, 2026 · NCT07420400Encore PFO Closure Device - The PerFOrm Trial
Recruiting
Ages 18 to 60 · All sexes · Updated Sep 19, 2024 · NCT05537753From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.