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COVID-19 and Coronavirus Infections clinical trials recruiting in the U.S.

24 studies for COVID-19 and Coronavirus Infections are recruiting participants at sites across the United States.

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By state

Recently updated studies

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05624450

A Study of COVID-19 Vaccine(s) in Children and Adults

RecruitingPhase 3Healthy volunteers welcome
Ages 5 and older · All sexes · Updated Sep 28, 2026 · NCT07798648

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07013474

Viral Infections in Healthy and Immunocompromised Hosts

RecruitingObservational studyHealthy volunteers welcome
6 Months – 120 Years · All sexes · Updated Sep 14, 2026 · NCT01306084

Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 9, 2026 · NCT04772170

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

RecruitingObservational studyHealthy volunteers welcome
Ages 0 to 20 · All sexes · Updated Aug 21, 2026 · NCT04278404

A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses

RecruitingPhase 1/2Healthy volunteers welcome
Ages 40 to 64 · All sexes · Updated Aug 18, 2026 · NCT06810934

Respiratory Virus Sampling and Repository

RecruitingObservational study
Ages 3 and older · All sexes · Updated Aug 17, 2026 · NCT05266222

A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age

RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 64 · All sexes · Updated Aug 7, 2026 · NCT07730450

Long-term Impact of Infection With Novel Coronavirus (COVID-19)

RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Jul 23, 2026 · NCT04362150

COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Jun 24, 2026 · NCT04391816

Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

RecruitingPhase 3
All ages · All sexes · Updated Jun 23, 2026 · NCT03808922

Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT01904188

Impact of the Coronavirus (COVID-19) on Patients With Cancer

RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Apr 27, 2026 · NCT04330521

ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Apr 8, 2026 · NCT04367857

A Study to Investigate the Immunogenicity and Safety of mRNA COVID-19 Variant-containing Vaccine Formulations

RecruitingPhase 4Healthy volunteers welcome
6 Months · All sexes · Updated Mar 27, 2026 · NCT06585241

Understanding Immunity to the Flu Vaccine in COVID-19 Patients

RecruitingObservational studyHealthy volunteers welcome
Ages 9 to 64 · All sexes · Updated Mar 18, 2026 · NCT04579588

Determinants of SARS (Severe Acute Respiratory Syndrome)-COV2 (COVID-19) Persistence After Convalescence

RecruitingObservational study
Ages 7 and older · All sexes · Updated Nov 5, 2025 · NCT04448145

Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study

RecruitingHealthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Sep 5, 2025 · NCT05868239

Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure

RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 28, 2021 · NCT04445285

Clazakizumab vs. Placebo - COVID-19 Infection

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 31, 2020 · NCT04494724

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.