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Homozygous Familial Hypercholesterolemia clinical trials recruiting in the U.S.
6 studies for Homozygous Familial Hypercholesterolemia are recruiting participants at sites across the United States.
Recently updated studies
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
RecruitingPhase 1
Ages 18 to 75 · All sexes · Updated Sep 18, 2026 · NCT07491172Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
RecruitingPhase 3
Ages 2 to 100 · All sexes · Updated Sep 18, 2026 · NCT05682378Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
RecruitingPhase 3
Ages 2 to 11 · All sexes · Updated Jul 24, 2026 · NCT06597006The Rogosin Institute Homozygous Familial Hypercholesterolemia Repository
RecruitingObservational study
All ages · All sexes · Updated Apr 6, 2026 · NCT01109368The ORIGIN-FH Study
Recruiting
Ages 18 and older · All sexes · Updated Mar 13, 2026 · NCT07470723HoFH, the International Clinical Collaborators Registry
RecruitingObservational study
All ages · All sexes · Updated Dec 18, 2025 · NCT04815005From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.