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Alcohol Use Disorder (AUD) clinical trials recruiting in the U.S.

141 studies for Alcohol Use Disorder (AUD) are recruiting participants at sites across the United States.

An alcohol use disorder (AUD) is drinking that causes distress and harm. AUD can range from mild to severe (alcoholism). Learn the signs that you may have a problem with drinking.

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Recently updated studies

Hepatic Lipid Metabolism-Alcohol Use Disorder

RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT07191561

tAN for Substance Use Disorder

Recruiting
Ages 18 to 64 · All sexes · Updated Sep 28, 2026 · NCT07281261

SMART-r: Substance Monitoring and Active Relapse Tracking Repository

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Sep 28, 2026 · NCT06676059

Environment and Alcohol: A Pilot Study

RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 100 · All sexes · Updated Sep 28, 2026 · NCT06860607

Greek Connections Study

RecruitingHealthy volunteers welcome
Ages 18 to 29 · All sexes · Updated Sep 24, 2026 · NCT07839026

A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07219966

A Study of Brenipatide in Participants With Alcohol Use Disorder

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 22, 2026 · NCT07219953

Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE)

RecruitingPhase 3Healthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Sep 21, 2026 · NCT07218354

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05619185

Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 21, 2026 · NCT07214207

Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

RecruitingPhase 1
Ages 21 to 65 · All sexes · Updated Sep 21, 2026 · NCT06335407

Spironolactone in Alcohol Use Disorder (SAUD)

RecruitingPhase 1
Ages 21 to 99 · All sexes · Updated Sep 21, 2026 · NCT05807139

PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Sep 18, 2026 · NCT06795581

Imaging Mitochondrial Complex-I in Alcohol Use Disorder

RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 17, 2026 · NCT07825818

Exercise Training Decreases Alcohol Consumption and Tissue Injury by an FGF21-dependent Mechanism

Recruiting
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07824089

PT150 Drug for Use in Alcohol Use Disorder

RecruitingPhase 1
Ages 21 to 55 · All sexes · Updated Sep 16, 2026 · NCT06712602

Cannabidiol and Alcohol Use Disorder Phenotypes

RecruitingPhase 2
Ages 21 to 65 · All sexes · Updated Sep 16, 2026 · NCT07279558

Characterization Imaging Instruments in Alcoholics and Non-Alcoholics

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT02108080

The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06319872

Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 15, 2026 · NCT05677321

Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06518785

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

RecruitingPhase 1
Ages 21 to 65 · All sexes · Updated Sep 10, 2026 · NCT06070649

Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

RecruitingEarly phase 1Healthy volunteers welcome
Ages 21 to 70 · All sexes · Updated Sep 9, 2026 · NCT05957159

Role of Phosphatidylethanol in Predicting Perioperative Outcomes of Admitted Patients at UHCMC

RecruitingObservational study
Ages 21 to 79 · All sexes · Updated Sep 4, 2026 · NCT06864819

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.