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Alcohol Use Disorder (AUD) clinical trials recruiting in the U.S.

138 studies for Alcohol Use Disorder (AUD) are recruiting participants at sites across the United States.

An alcohol use disorder (AUD) is drinking that causes distress and harm. AUD can range from mild to severe (alcoholism). Learn the signs that you may have a problem with drinking.

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Recently updated studies

SMART-r: Substance Monitoring and Active Relapse Tracking Repository

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Nov 13, 2026 · NCT06676059

Environment and Alcohol: A Pilot Study

RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 100 · All sexes · Updated Nov 13, 2026 · NCT06860607

Sex Differences in the Response to Abstinence From Alcohol.

RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 35 · All sexes · Updated Nov 12, 2026 · NCT03827460

Spironolactone in Alcohol Use Disorder (SAUD)

RecruitingPhase 1
Ages 21 to 99 · All sexes · Updated Nov 9, 2026 · NCT05807139

NIAAA Natural History Protocol

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Nov 5, 2026 · NCT02231840

Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

RecruitingPhase 2/3
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT06559995

Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes

RecruitingPhase 1
Ages 18 to 68 · All sexes · Updated Nov 4, 2026 · NCT07772960

Imaging Mitochondrial Complex-I in Alcohol Use Disorder

RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Nov 3, 2026 · NCT07825818

Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving

RecruitingPhase 2/3
Ages 21 to 65 · All sexes · Updated Nov 3, 2026 · NCT07148843

Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

RecruitingPhase 4
Ages 21 to 65 · All sexes · Updated Nov 2, 2026 · NCT06269627

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

RecruitingPhase 1
Ages 21 to 70 · All sexes · Updated Nov 2, 2026 · NCT07027839

Phase 2 Study of Apremilast in Women and Men With Alcohol Use Disorder

RecruitingPhase 2Healthy volunteers welcome
Ages 21 to 65 · All sexes · Updated Oct 30, 2026 · NCT07029529

Tdcs And cogNitive traininG cOmbined for AUD (TANGO)

Recruiting
Ages 18 to 65 · All sexes · Updated Oct 30, 2026 · NCT05062369

Developing a Novel Human Laboratory Paradigm for AUD Medication Screening

RecruitingHealthy volunteers welcome
Ages 21 to 65 · All sexes · Updated Oct 30, 2026 · NCT06489782

Peer Support for Liver Transplant Recipients With History of ALD

Recruiting
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07397598

PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Oct 27, 2026 · NCT06795581

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

RecruitingPhase 2/3
Ages 21 to 65 · All sexes · Updated Oct 21, 2026 · NCT06807918

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT05619185

Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms

RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Oct 19, 2026 · NCT06484075

AAT for Alcohol Use Disorder in Veterans

Recruiting
Ages 18 to 65 · All sexes · Updated Oct 16, 2026 · NCT05372029

Suvorexant for Treatment of AUD and PTSD

RecruitingPhase 2
Ages 21 to 65 · All sexes · Updated Oct 14, 2026 · NCT06679062

Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)

RecruitingPhase 1
Ages 21 to 65 · All sexes · Updated Oct 13, 2026 · NCT07559500

Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Oct 13, 2026 · NCT05677321

Hepatic Lipid Metabolism-Alcohol Use Disorder

RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Oct 8, 2026 · NCT07191561

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.