Sex Differences in the Response to Abstinence From Alcohol.

Inclusion Criteria:

* Moderate social drinkers
* Able to understand/complete questionnaires and procedures in English
* Body mass index (BMI) between 18.5 and 32 kg/m2
* Have venous access sufficient to allow blood sampling

Exclusion Criteria:

* Pregnant or breast-feeding women, or women who intend to become pregnant
* Do not attest to using accepted forms of birth control for the infusion phase of the study
* Current treatment for, or desire to be treated for, any substance use disorder or court ordered to not drink alcohol
* History of significant adverse reaction to alcohol
* Medical disorders or other conditions such as alcohol withdrawal seizures or delirium tremens that may influence study outcome or participant safety
* Medications (past 30 days) that could influence data or participant safety (e.g. antidepressants, antipsychotics, benzodiazepines, etc.) as determined by investigators
* DSM 5 Disorders (non AUD) or current/history of neurological disease of cerebral origin, or head injury with \> 20 min loss of consciousness
* Positive breath alcohol reading on arrival at any study visit
* Actively suicidal (for example, any suicide attempts within the past year or any current suicidal intent, including a plan) or are at serious suicidal risk, by clinical judgment of the investigator
* Any condition for which the principal investigators determine it is unsafe or not prudent to enroll