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Brain Diseases clinical trials recruiting in the U.S.

45 studies for Brain Diseases are recruiting participants at sites across the United States.

Brain diseases affect different functions of the body from memory, speech, thinking clearly, how well the different organs work, or even movement.

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Recently updated studies

kTMP-Enhanced Motor Rehabilitation for Chronic Stroke Recovery (KULMINATE) Pilot

Recruiting
Ages 18 to 80 · All sexes · Updated Sep 29, 2026 · NCT07631078

Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Sep 29, 2026 · NCT06615973

CoMind Early Feasibility Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06368648

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595

Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control

Recruiting
Ages 18 to 75 · All sexes · Updated Sep 18, 2026 · NCT07056361

Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Sep 18, 2026 · NCT07056348

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05386108

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

RecruitingPhase 1
36 Months – 22 Years · All sexes · Updated Sep 4, 2026 · NCT03911388

A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 1, 2026 · NCT07459647

Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)

RecruitingObservational study
7 Months – 15 Months · All sexes · Updated Aug 31, 2026 · NCT06805695

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

RecruitingPhase 2
Ages 55 to 90 · All sexes · Updated Aug 27, 2026 · NCT06887192

Natural History of Stroke: Cause and Development

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Aug 27, 2026 · NCT00009243

Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage

Recruiting
Ages 50 and older · All sexes · Updated Aug 27, 2026 · NCT06993142

A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Aug 24, 2026 · NCT06297590

Inflammatory and Infectious Diseases of the Nervous System

RecruitingObservational study
Ages 2 to 110 · All sexes · Updated Aug 20, 2026 · NCT02435810

Brain Development Research Program

RecruitingObservational study
All ages · All sexes · Updated Aug 17, 2026 · NCT00305305

Transplantation of Human iPS Cell-derived Dopaminergic Progenitors (CT1-DAP001) for Parkinson's Disease (Phase I/II)

RecruitingPhase 1
Ages 40 to 75 · All sexes · Updated Aug 17, 2026 · NCT06482268

An Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC Deficiency

RecruitingPhase 3
24 Hours – 7 Months · Men · Updated Aug 12, 2026 · NCT06255782

SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05812755

Neonatal Neurological Observation With Video AI

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Jul 15, 2026 · NCT07628829

A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

RecruitingPhase 1/2
Ages 35 to 85 · All sexes · Updated Jul 10, 2026 · NCT05462106

Auricular VNS Following Intracerebral Hemorrhage

Recruiting
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT06799390

F 18 T807 Tau PET Imaging of Alzheimer's Disease

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT02414347

Neuroimaging in Healthy Aging and Senile Dementia (HASD_IND)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT04579120

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.