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Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
Chronic Stimulation of the Motor Ventral Thalamus (VOP/VIM) for Motor Control in Humans
Who can join
Ages 18 to 80 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Movement disorder patients ≥18 years of age and \< 80 years of age, who will be implanted with DBS for treatment of motor symptoms. * Subject has provided written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization, where applicable, prior to any study-related procedures. Exclusion Criteria: * History of seizure disorders * Vasovagal response history and loss of consciousness history * Severe behavioral or cognitive problems that preclude participation in the study, in the opinion of the investigator would impact participation in the study. * Any serious disease or disorder (e.g. cancer, severe cardiac or respiratory disease, neurological conditions other than current movement disorder) or cognitive impairments that could impair ability to participate in this study. * Females who are pregnant or breastfeeding.
About the study
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without stimulation. DBS parameters would be adjusted prior to motor testing. Patients would then participate in multiple sessions performing contralateral upper extremity movement tasks measuring movement speed, grip strength, and strength modulation, facial movement, swallowing, and speech tasks.
What is being tested
- Deep Brain Stimulation (DBS) of the Motor Thalamus (device)
Sponsor: Jorge Gonzalez-Martinez · Participants: 60 · Started: May 10, 2022
Contact the study team
- Cierra Clark, MS · Phone: 240-441-4216
- Elvira Pirondini, PhD · Phone: 412-636-0595
Official record on ClinicalTrials.gov — NCT07056348
Locations in the U.S.
| Pennsylvania | University of Pittsburgh, Pittsburgh |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.