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Brain Tumors clinical trials in North Carolina
21 studies for Brain Tumors are looking for participants at sites in North Carolina.
Cities in North Carolina
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
- Atrium Health Levine Cancer Institute, Charlotte
- Atrium Health Wake Forest Baptist, Winston-Salem
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07326566A Study of Navlimetostat (BMS-986504) Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
- Local Institution - 0100, Durham
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07492680A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma
- Duke University, Durham
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07428616REMASTer: REcurrent Brain Metastases After SRS Trial
- Wake Forest Baptist Medical Center, Winston-Salem
Recruiting
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT05124912Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors
- Duke Cancer Center, Durham
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT05480644Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
- Duke University School of Medicine, Durham
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT05786924Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
- Duke University, Durham
- Atrium Health Wake Forest Baptist, Winston-Salem
RecruitingPhase 3
Ages 18 to 100 · All sexes · Updated Oct 13, 2026 · NCT05317858A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
- Wake Forest University at Clemmons, Clemmons
- Southeastern Medical Oncology Center-Clinton, Clinton
- Southeastern Medical Oncology Center-Goldsboro, Goldsboro
- and 4 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013A Phase 1/1b Study of IAM1363 in HER2 Cancers
- Duke Cancer Institute, Durham
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871Targeted Pediatric High-Grade Glioma Therapy
- Duke University Health System, Durham
RecruitingObservational study
12 Months – 39 Years · All sexes · Updated Sep 8, 2026 · NCT05839379Study of Olutasidenib and Temozolomide in HGG
- Duke University Health System, Durham
RecruitingPhase 2
Ages 12 to 39 · All sexes · Updated Sep 1, 2026 · NCT06161974ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas
- Duke University Medical Center, Durham
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT05609994MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
- University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT04073966B6 Administration for Levetiracetam-Associated Neurobehavioral Changes and Epilepsy
- Duke University Medical Center, Durham
Recruiting
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT07271966Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
- Vidant Heath - ECU Medical Center, Greenville
- Atlantic Brain & Spine, Wilmington
RecruitingObservational study
All ages · All sexes · Updated Jul 22, 2026 · NCT04427384Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance
- Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 17, 2026 · NCT05692635Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
- Cone Health Cancer Center, Greensboro
- Wake Forest University Health Sciences, Winston-Salem
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jun 9, 2026 · NCT03550391Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
- Duke University Health System, Durham
RecruitingPhase 2
12 Months – 39 Years · All sexes · Updated May 29, 2026 · NCT05843253Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc
- Lineberger Comprehensive Cancer Center, Chapel Hill
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT05366179Key Longitudinal Associations With Risk and Glioblastoma Outcomes
- Duke University, Durham
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jan 20, 2026 · NCT06625684APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
- University of North Carolina, Chapel Hill
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 27, 2025 · NCT03175224From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.