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Brain Tumors clinical trials recruiting in the U.S.

199 studies for Brain Tumors are recruiting participants at sites across the United States.

A brain tumor is a growth of abnormal cells in the brain tissue. Learn the types of tumors, symptoms, how they are diagnosed and treatment options.

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Recently updated studies

Evaluation and Treatment of Neurosurgical Disorders

RecruitingObservational study
Ages 4 to 99 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT00060541

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

RecruitingPhase 1/2
Ages 18 to 99 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07416188

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07326566

SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain Metastases

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT04923542

C-SMART vs BE Well for Patients With Brain Tumors

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07224503

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06047379

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

RecruitingPhase 1
Ages 18 to 80 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT06389591

Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 23, 2026 ยท NCT05733312

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07248228

Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07470606

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 21, 2026 ยท NCT04977375

REMIND Maintenance Radiotherapy for Newly Diagnosed Glioblastoma

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 21, 2026 ยท NCT07831772

Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis

RecruitingEarly phase 1
Ages 18 to 99 ยท All sexes ยท Updated Sep 21, 2026 ยท NCT06055790

Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07053033

PilotStudyAssessSafeActiveSurveillancApproachLocalThe Pa w/BrainMetsUndergoinCNSPenetratSystemicThe

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07827001

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT05048212

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07227610

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 16, 2026 ยท NCT05786924

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

Recruiting
Ages 15 to 120 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07374692

Development of MRF for Characterization of Brain Tumors After Radiotherapy

RecruitingHealthy volunteers welcome
Ages 18 to 60 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06101069

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

RecruitingPhase 2
59 Months ยท All sexes ยท Updated Sep 15, 2026 ยท NCT05535166

OBSERVE: A Pilot Study Of Omission Of Brain Metastasis Stereotactic Radiosurgery Following Resection With CNS-Active Systemic Therapy

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07655583

Home-based Vision Rehabilitation Guided by Brain Imaging

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 14, 2026 ยท NCT07635329

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.