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Brain Tumors clinical trials recruiting in the U.S.

200 studies for Brain Tumors are recruiting participants at sites across the United States.

A brain tumor is a growth of abnormal cells in the brain tissue. Learn the types of tumors, symptoms, how they are diagnosed and treatment options.

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Recently updated studies

000860: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

RecruitingPhase 1/2
Ages 15 to 99 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT05588141

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07326566

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 12, 2026 ยท NCT03418961

Tumor Related Epilepsy

RecruitingObservational study
Ages 8 to 99 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT02639325

Evaluation and Treatment of Neurosurgical Disorders

RecruitingObservational study
Ages 4 to 99 ยท All sexes ยท Updated Nov 10, 2026 ยท NCT00060541

A Phase I Clinical Study of YN003 in the Treatment of Glioma

RecruitingPhase 1
Ages 18 to 70 ยท All sexes ยท Updated Nov 10, 2026 ยท NCT07929909

Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors

Recruiting
Ages 18 and older ยท All sexes ยท Updated Nov 10, 2026 ยท NCT02754544

A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Nov 10, 2026 ยท NCT05342454

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

RecruitingPhase 1/2
Ages 18 to 120 ยท All sexes ยท Updated Nov 6, 2026 ยท NCT06161519

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 40 and older ยท All sexes ยท Updated Nov 4, 2026 ยท NCT05366881

Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-Being

Recruiting
Ages 18 and older ยท All sexes ยท Updated Nov 3, 2026 ยท NCT07628647

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

RecruitingPhase 1
Ages 3 to 25 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05106296

Mapping of Human Cognition

Recruiting
Ages 18 to 75 ยท All sexes ยท Updated Nov 2, 2026 ยท NCT05989893

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

RecruitingPhase 1
Ages 4 and older ยท All sexes ยท Updated Oct 30, 2026 ยท NCT04573140

rTMS for Postoperative Brain Tumor Patients

Recruiting
Ages 22 to 65 ยท All sexes ยท Updated Oct 29, 2026 ยท NCT07530536

Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer

RecruitingPhase 4
Ages 18 and older ยท Women ยท Updated Oct 29, 2026 ยท NCT06072807

An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregivers, ET-NEURO Trial

RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 28, 2026 ยท NCT07278440

Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).

RecruitingPhase 2
Ages 1 to 26 ยท All sexes ยท Updated Oct 28, 2026 ยท NCT07680439

A Study of Zanzalintinib in Participants With Recurrent or Progressive Meningioma

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 28, 2026 ยท NCT07428616

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Oct 21, 2026 ยท NCT06810544

Safety & Efficacy/Tolerability of Rhenium-186 NanoLiposomes (186RNL) for Patients Who Received a Prior 186RNL Treatment

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 21, 2026 ยท NCT05460507

EXercise-induced PhysioLogical Adaptations In Neurological Disorders

RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Oct 20, 2026 ยท NCT07883720

Development of MRF for Characterization of Brain Tumors After Radiotherapy

RecruitingHealthy volunteers welcome
Ages 18 to 60 ยท All sexes ยท Updated Oct 20, 2026 ยท NCT06101069

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.