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Cardiomyopathy clinical trials recruiting in the U.S.

44 studies for Cardiomyopathy are recruiting participants at sites across the United States.

Cardiomyopathy is a disease that causes the heart to become enlarged, thick, or stiff. Read about the different types, their symptoms, and treatments.

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Recently updated studies

Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia

RecruitingPhase 1
Ages 12 to 50 · All sexes · Updated Sep 28, 2026 · NCT05302271

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

RecruitingObservational studyHealthy volunteers welcome
Ages 1 to 100 · All sexes · Updated Sep 22, 2026 · NCT01143454

ATR 1072 in Participants With PRKAG2 Syndrome

RecruitingPhase 1/2
Ages 18 to 65 · All sexes · Updated Sep 18, 2026 · NCT07738107

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 16, 2026 · NCT07052903

Targeted Ablation to Isolate Scar Channels Causing Ventricular Tachycardia

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07814079

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07358078

Early Screening and Treatment of Heart Complication in Sickle Cell Disease

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07023666

Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging

RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Sep 8, 2026 · NCT03581318

Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy

RecruitingPhase 2
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT07721025

Clinical Course Of Disease In Participants With FA-CM

RecruitingObservational study
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT06865482

Sodium/Glucose Cotransporter-2 Inhibitors (SGLT2i) Therapy in Duchenne Cardiomyopathy

RecruitingPhase 1
Ages 8 to 18 · Men · Updated Aug 24, 2026 · NCT07172971

Impella Reverse Remodeling in End-Stage Heart Failure

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06800716

Cardiovascular Multimodality Imaging Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06610019

Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

RecruitingPhase 2
Ages 0 to 16 · All sexes · Updated Aug 10, 2026 · NCT06080074

TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT05507879

Characterization of the Cardiac Phenotype of Friedreich's Ataxia (FRDA)

RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 50 · All sexes · Updated Jul 29, 2026 · NCT02316314

Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis

RecruitingPhase 4
Ages 18 to 80 · All sexes · Updated Jul 29, 2026 · NCT07695701

Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials

RecruitingObservational study
All ages · All sexes · Updated Jul 28, 2026 · NCT07674758

Danon Disease Natural History Study

RecruitingObservational study
Ages 8 and older · All sexes · Updated Jul 28, 2026 · NCT06214507

The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT05034432

Pediatric Cardiomyopathy Mutation Analysis

RecruitingObservational study
All ages · All sexes · Updated Jun 22, 2026 · NCT02432092

Psychosocial Support for Patients With Takotsubo Syndrome

Recruiting
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT05977049

Mechanisms of Diuretic Resistance in Heart Failure, Aim 3

RecruitingPhase 1
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06209359

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.