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Targeted Ablation to Isolate Scar Channels Causing Ventricular Tachycardia

Segmental Substrate Isolation for the Treatment of Ventricular Tachycardia in Patients With Structural Heart Disease

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients with structural heart disease undergoing VT ablation

Exclusion Criteria:

1. Unable or unwilling to sign consent
2. Cardiogenic shock or NYHA Class IV heart failure and not a candidate for mechanical circulatory support for the procedure (percutaneous left ventricular assist device (LVAD), extracorporeal membrane oxygenation, or implanted LVAD)
3. Absence of substrate during initial voltage mapping

About the study

The goal of this study is to map conducting channels within scar that cause ventricular tachycardia (VT) in patients with scar in their hearts in order to block these channels from causing VT with targeted radiofrequency ablation (cautery).

Participants undergoing VT ablation mapping of these channels by pacing many sites within the scar area and determining where these channels exit the scar into normal tissue. These exits will be ablated. Immediate success and success at 1 year will be evaluated.

What is being tested

• Selective Substrate Isolation (procedure)

Sponsor: New York Medical College · Participants: 30 · Started: Mar 27, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07814079

Locations in the U.S.

Conditions

• Ventricular Tachycardia
• Cardiomyopathy

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.