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Chronic Progressive Multiple Sclerosis clinical trials recruiting in the U.S.

18 studies for Chronic Progressive Multiple Sclerosis are recruiting participants at sites across the United States.

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Recently updated studies

A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis

RecruitingPhase 3
Ages 18 to 60 · All sexes · Updated Sep 23, 2026 · NCT07299019

A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

RecruitingPhase 3
Ages 18 to 60 · All sexes · Updated Sep 22, 2026 · NCT07067463

Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

RecruitingPhase 1/2
Ages 18 to 65 · All sexes · Updated Sep 21, 2026 · NCT07477639

Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

RecruitingPhase 3
Ages 18 to 55 · All sexes · Updated Sep 16, 2026 · NCT04047628

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

RecruitingPhase 1/2
Ages 18 to 120 · All sexes · Updated Aug 27, 2026 · NCT03109288

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Jul 29, 2026 · NCT07225504

Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy

RecruitingPhase 1/2
Ages 18 to 55 · All sexes · Updated Jul 2, 2026 · NCT05359653

Obe-cel in Refractory Progressive Forms of Multiple Sclerosis

RecruitingPhase 1
Ages 18 to 60 · All sexes · Updated Mar 23, 2026 · NCT07139743

Intermittent Hypoxia in Persons With Multiple Sclerosis

Recruiting
Ages 18 to 75 · All sexes · Updated Mar 20, 2026 · NCT06276634

Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS

Recruiting
Ages 18 to 75 · All sexes · Updated Feb 23, 2026 · NCT06390930

Bringing the Outdoors In: Virtual Nature Walks for Depression in Multiple Sclerosis (MS) Patients

Recruiting
Ages 18 and older · All sexes · Updated Feb 12, 2026 · NCT07392879

Home Based Functional Balance Intervention for Multiple Sclerosis

Recruiting
Ages 40 to 90 · All sexes · Updated Jan 21, 2026 · NCT07355387

"Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 31, 2025 · NCT07222618

Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis

Recruiting
Ages 22 to 75 · All sexes · Updated Sep 24, 2025 · NCT05964829

MS-ResearchBiomarkerS

RecruitingObservational studyHealthy volunteers welcomeMentions payment for participants
Ages 18 and older · All sexes · Updated Feb 6, 2024 · NCT05204459

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.