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Cirrhosis clinical trials recruiting in the U.S.

36 studies for Cirrhosis are recruiting participants at sites across the United States.

Cirrhosis is caused when scar tissue replaces healthy tissue in the liver because of chronic injury. Learn how cirrhosis is diagnosed and treated.

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Recently updated studies

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 28, 2026 · NCT05832229

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

Recruiting
Ages 21 to 65 · All sexes · Updated Sep 28, 2026 · NCT05166499

Molecular Mechanism of Exercise in Cirrhosis

Recruiting
Ages 21 to 65 · All sexes · Updated Sep 28, 2026 · NCT05982769

National Liver Cancer Screening Trial

RecruitingPhase 4
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06084234

Study of AZD2389 Safety, Tolerability, and Pharmacodynamics in Adults With Steatotic Liver Disease and Advanced Fibrosis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07610837

Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis

RecruitingHealthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 21, 2026 · NCT03208868

Fibrosis Lessens After Metabolic Surgery

RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Jul 31, 2026 · NCT06374875

Measuring Patient Reported Needs in Outpatient Liver Disease Management

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT07191886

Multi-analyte Blood Test Clinical Trial

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05199259

Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05181826

High Dose Albumin in Refractory Ascites

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT05867602

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Recruiting
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06138821

Digoxin In NASH (CODIN)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated May 26, 2026 · NCT06588699

Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

RecruitingObservational study
Ages 18 to 75 · All sexes · Updated May 7, 2026 · NCT06950788

COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT05692024

Siemens Biomarker Multi-modality

Recruiting
Ages 18 and older · All sexes · Updated Apr 3, 2026 · NCT07495332

Initial Resuscitation for Acute Kidney Injury in Cirrhosis

Recruiting
Ages 18 and older · All sexes · Updated Mar 13, 2026 · NCT06525623

Transitional Care Program for Fluid Overload in Cirrhosis

Recruiting
Ages 18 and older · All sexes · Updated Mar 9, 2026 · NCT06174272

Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Feb 19, 2026 · NCT05526144

Study of Tremelimumab and Durvalumab (MEDI4736) (T300+D) in Advanced Hepatocellular Carcinomas With Child-Pugh-B Cirrhosis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jan 6, 2026 · NCT06526104

A Study of SIPLIZUMAB in AILD and LT Patients

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 24, 2025 · NCT06455280

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT06871111

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

RecruitingObservational study
Ages 18 to 80 · All sexes · Updated Oct 20, 2025 · NCT04613921

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.