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Cirrhosis clinical trials recruiting in the U.S.

37 studies for Cirrhosis are recruiting participants at sites across the United States.

Cirrhosis is caused when scar tissue replaces healthy tissue in the liver because of chronic injury. Learn how cirrhosis is diagnosed and treated.

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Recently updated studies

Endoscopic Ultrasound Shear Wave Elastography Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06592820

Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 9, 2026 · NCT07631637

Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 5, 2026 · NCT07854782

High Dose Albumin in Refractory Ascites

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT05867602

Study of AZD2389 Safety, Tolerability, and Pharmacodynamics in Adults With Steatotic Liver Disease and Advanced Fibrosis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07610837

Evaluation of Non-Invasive Tests for Metabolic Liver Disease

RecruitingObservational study
Ages 18 to 75 · All sexes · Updated Oct 26, 2026 · NCT07122700

Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT01757730

Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis

RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Oct 14, 2026 · NCT06265272

HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

Recruiting
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT05205954

Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT05028829

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 28, 2026 · NCT05832229

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

Recruiting
Ages 21 to 65 · All sexes · Updated Sep 28, 2026 · NCT05166499

Molecular Mechanism of Exercise in Cirrhosis

Recruiting
Ages 21 to 65 · All sexes · Updated Sep 28, 2026 · NCT05982769

National Liver Cancer Screening Trial

RecruitingPhase 4
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06084234

Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis

RecruitingHealthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 21, 2026 · NCT03208868

Fibrosis Lessens After Metabolic Surgery

RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Jul 31, 2026 · NCT06374875

Measuring Patient Reported Needs in Outpatient Liver Disease Management

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT07191886

Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05181826

Multi-analyte Blood Test Clinical Trial

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT05199259

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Recruiting
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06138821

Digoxin In NASH (CODIN)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated May 26, 2026 · NCT06588699

Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

RecruitingObservational study
Ages 18 to 75 · All sexes · Updated May 7, 2026 · NCT06950788

COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT05692024

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.