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Constipation clinical trials recruiting in the U.S.
17 studies for Constipation are recruiting participants at sites across the United States.
Feeling "backed-up" or like you need to "go" but just can't? Read some of the reasons why this could be happening and learn some prevention tips.
By state
Recently updated studies
A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Constipation (IBS-C)
RecruitingPhase 2
Ages 18 to 75 ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07545772Home Transcutaneous Electrical Acustimulation (TEA)
RecruitingPhase 2/3
Ages 18 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT05519683Understanding Mechanisms of Normal and Disordered Defecation
RecruitingHealthy volunteers welcome
Ages 18 to 80 ยท All sexes ยท Updated Aug 21, 2026 ยท NCT03842007Radicle GI HealthTM VNB: A Study Assessing the Impact of Health and Wellness Products on Constipation and Related Health Outcomes
RecruitingHealthy volunteers welcome
Ages 21 to 105 ยท All sexes ยท Updated Aug 20, 2026 ยท NCT07713810Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen
RecruitingPhase 4Healthy volunteers welcome
Ages 2 to 18 ยท All sexes ยท Updated Aug 18, 2026 ยท NCT05821309A Study of Microbiome Transplantation for the Treatment of Constipation and/or Significant Bloating in Patients With Systemic Sclerosis
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 8, 2026 ยท NCT06827977Indiana University Gastrointestinal Motility Diagnosis Registry
RecruitingObservational study
All ages ยท All sexes ยท Updated Jun 16, 2026 ยท NCT04506593A Study of Herbal Supplements in Cancer Survivors With Constipation
Recruiting
Ages 18 and older ยท All sexes ยท Updated May 22, 2026 ยท NCT07091084Optimization of Postoperative Bowel Habits
Recruiting
Ages 18 and older ยท Women ยท Updated Feb 27, 2026 ยท NCT06335797Pyridostigmine for the Treatment of Constipation in Parkinson Disease
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Feb 23, 2026 ยท NCT05603715Impact of Weizmannia (Bacillus) Coagulans JBI-YZ6.3 on Gut Health and Fecal Microbiome Changes
RecruitingHealthy volunteers welcome
Ages 18 to 50 ยท All sexes ยท Updated Feb 5, 2026 ยท NCT07388264Management of Dyssynergic Defecation
Recruiting
Ages 18 to 80 ยท All sexes ยท Updated Nov 10, 2025 ยท NCT07225803Fecobionics in Biofeedback Therapy in Dyssynergia Patients
Recruiting
Ages 21 to 75 ยท All sexes ยท Updated Oct 21, 2025 ยท NCT05807321Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
Recruiting
Ages 18 and older ยท All sexes ยท Updated Jun 26, 2025 ยท NCT05989763Preop Laxatives in Robotic Urologic Surgery
RecruitingPhase 4Healthy volunteers welcome
Ages 30 to 100 ยท All sexes ยท Updated May 30, 2025 ยท NCT05805436Tenapanor in Synucleinopathy-Related Constipation
RecruitingPhase 2
Ages 50 to 89 ยท All sexes ยท Updated Feb 10, 2025 ยท NCT06460038Viome Nutritional Programs to Improve Clinical Outcomes for Gastrointestinal Conditions
Recruiting
Ages 25 to 75 ยท All sexes ยท Updated Jan 29, 2025 ยท NCT05465629From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.