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Critical Illness clinical trials recruiting in the U.S.

45 studies for Critical Illness are recruiting participants at sites across the United States.

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Recently updated studies

Behavioral Economic & Staffing Strategies in the ICU

Recruiting
Ages 19 and older · All sexes · Updated Sep 29, 2026 · NCT06184945

Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients

RecruitingPhase 2
Ages 18 to 99 · All sexes · Updated Sep 2, 2026 · NCT07639359

Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children

RecruitingObservational study
1 Day – 17 Years · All sexes · Updated Aug 27, 2026 · NCT07613918

Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

Recruiting
Up to age 18 · All sexes · Updated Aug 24, 2026 · NCT04989790

Exogenous Ketone Supplementation in ICU Delirium

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT07364162

Azithromycin for Critical Asthma - Pediatrics

RecruitingPhase 2/3
Ages 3 to 17 · All sexes · Updated Aug 11, 2026 · NCT06223828

COMPARE-VENT Feasibility Pilot Study

Recruiting
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT07656259

Improving Needs Among Older Adults

Recruiting
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06588556

PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

RecruitingPhase 1/2
7 Days – 28 Days · All sexes · Updated Jul 14, 2026 · NCT07101640

The Effects of Endotracheal Suctioning on Pain and Serum Markers

Recruiting
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06692400

Digital and Plasma Biomarkers in Delirium

RecruitingObservational study
Ages 65 and older · All sexes · Updated Jul 9, 2026 · NCT07694206

Pervasive Sensing and AI in Intelligent ICU

RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT05127265

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT06066502

Muscle Recovery After Critical Illness

RecruitingObservational study
Ages 18 and older · Men · Updated Jun 26, 2026 · NCT05537298

Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06341972

Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery After a Critical Illness

RecruitingObservational study
Ages 65 and older · All sexes · Updated Jun 17, 2026 · NCT06006000

Preoperative Fasting vs. Not Fasting in Critically Ill Patients

Recruiting
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06751043

Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies

RecruitingPhase 2/3
Up to age 17 · All sexes · Updated Jun 8, 2026 · NCT04924322

Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

Recruiting
Ages 45 and older · All sexes · Updated Jun 3, 2026 · NCT06521086

NIBP Validation Study

RecruitingObservational study
All ages · All sexes · Updated May 26, 2026 · NCT05673408

iNO300 Therapy in Critically Ill Patients With Pneumonia

RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06950294

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.