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Optimizing Recovery in Trauma Patients by Integrating Enhanced Nutrition Delivery

Optimizing Recovery in Trauma Patients: Integrating Enhanced Nutrition Delivery With Muscle Assessments, Functional Outcomes and Quality of Life

Who can join

Ages 45 and older · All sexes

Inclusion Criteria:

* Patients who are at least 45 years old and presented to the Emergency Department as a leveled trauma
* Patients who have the ability to tolerate oral nutrition
* Patients who have had a standard of care CT scan this admission

Exclusion Criteria:

* Expected withdrawal of life-sustaining treatment within 48 hours
* Traumatic Brain Injury
* Presence of lower extremity fracture(s)
* Mechanical Ventilation
* Subjects for who the Investigator would recommend a different supplement based on their medical condition.
* Prisoner
* Pregnancy for women of child-bearing potential

About the study

This is a prospective, randomized, controlled trial designed to evaluate the impact of enhanced protein supplementation compared to a standard of care nutrition delivery in critically ill older adult trauma patients. Subjects will be randomized 1:1 to either enhanced nutrition or control arm. Subjects randomized to the enhanced nutrition arm will receive oral nutrition supplements (ONS) up to 3 times per day while in the hospital and for 4 weeks after discharge. Subjects in the standard of care arm will receive normal nutrition recommendations from their clinical providers. Participants in both groups will undergo non-invasive tests that measure how much energy (calories) they are using, body composition, and muscle mass.

What is being tested

• Nutrition Supplements - Fresubin KCAL Drinks (dietary supplement)

Sponsor: Duke University · Participants: 60 · Started: Feb 18, 2026

Contact the study team

• Paul Wischmeyer, MD · Phone: 919-681-9660
• Krista Haines, MD · Phone: 919-681-3784

Official record on ClinicalTrials.gov — NCT06521086

Locations in the U.S.

Conditions

• Critical Illness

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.