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Depression clinical trials in New York

61 studies for Depression are looking for participants at sites in New York.

Cities in New York

A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

  • Adams Clinical Bronx, The Bronx
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07775300

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

  • Ima Clinical Research - Nyc Midtown, New York
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)

  • NYU Langone Health, New York
Recruiting
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT06455527

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

  • Adams Clinical Harlem, New York
  • New York State Psychiatric Institute, New York
  • Davis Clinical (Adams Clinical Bronx), The Bronx
  • and 1 more
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt

  • New York Presbyterian Hospital/Weill Cornell Medicine, New York
  • Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, White Plains
Recruiting
Ages 50 to 90 · All sexes · Updated Sep 23, 2026 · NCT05183230

Brexanolone Lifting Outcomes Of Moms

  • Lipocine Investigational Site, Manhattan
RecruitingPhase 3
Ages 15 to 45 · Women · Updated Sep 16, 2026 · NCT07822321

Psilocybin as a Novel Therapy for Residual Anhedonia

  • NYU Langone Health, New York
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 15, 2026 · NCT07607938

Pattern Separation in Major Depressive Disorder

  • New York State Psychiatric Institute (NYSPI), New York
RecruitingPhase 1
Ages 18 to 50 · All sexes · Updated Sep 15, 2026 · NCT07139834

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

  • Roswell Park Center Institute, Buffalo
  • NYU Langone Health, New York
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

  • Seaport Investigator Site, Brooklyn
  • Seaport Investigator Site, Cedarhurst
  • Seaport Investigator Site, New York
  • and 1 more
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240

Behavioral Activation for Treatment of Depression in Autistic Adolescents With Below Average Intelligence

  • Stony Brook University, Stony Brook
Recruiting
Ages 12 to 17 · All sexes · Updated Sep 10, 2026 · NCT07812870

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

  • Bioscience Research, LLC, Mount Kisco
  • Fieve Clinical Research, Inc., New York
  • IMA Clinical Research, New York
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

  • Draig Clinical Site, New York
  • Draig Clinical Site, New York
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473

A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

  • Draig Clinical Site, New York
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 26, 2026 · NCT07300969

A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD

  • Weill Cornell Medicine, White Plains
Recruiting
Ages 60 and older · All sexes · Updated Aug 20, 2026 · NCT05081596

A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

  • Weill Cornell Medical Center, New York
RecruitingPhase 2
Ages 50 to 79 · All sexes · Updated Aug 20, 2026 · NCT05507138

Improving the Mental Health of Home Health Aides

  • 1199 SEIU Home Care Industry Education Fund, New York
  • Weill Cornell Medicine, New York
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT06071221

Psilocybin-Assisted Therapy for Intergenerational Trauma

  • The Parsons Research Center for Psychedelic Healing, New York
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 13, 2026 · NCT06899165

NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

  • Neurocrine Clinical Site, New York
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06911112

Psilocybin to Treat Depression in Spinal Cord Injury

  • James J. Peters Department of Veterans Affairs Medical Center, The Bronx
RecruitingPhase 1/2
Ages 22 and older · All sexes · Updated Aug 10, 2026 · NCT07251491

NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

  • Neurocrine Clinical Site, Cedarhurst
  • Neurocrine Clinical Site, New York
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06963021

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

  • Adams Clinical Harlem, New York
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

Mobile Cognitive Behavioral Therapy for Stroke

  • Weill Cornell Medicine, New York
Recruiting
Ages 40 to 79 · All sexes · Updated Aug 4, 2026 · NCT06689878

E-Mindfulness Approaches for Living After Breast Cancer

  • Mount Sinai Queens, Astoria
  • Glens Falls Hospital, Glens Falls
  • Mount Sinai Union Square, New York
  • and 8 more
RecruitingPhase 3
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

  • Integrative Clinical Trials, Brooklyn
  • Richmond Behavioral Associates, Staten Island
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation

  • Weill Cornell Medicine, New York
Recruiting
Ages 60 and older · All sexes · Updated Jul 29, 2026 · NCT06039930

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

  • Neurocrine Clinical Site, Cedarhurst
  • Neurocrine Clinical Site, Mount Kisco
  • Neurocrine Clinical Site, New York
  • and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Sleep More, Stress Less: 90-Day Trial of Neuralli Mood

  • Efforia - Decentralized United States Study, New York
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT07717385

Assessment of Music Experiences in Navigating Depression Part 2

  • Mount Sinai Union Square, New York
Recruiting
Ages 7 to 15 · All sexes · Updated Jul 17, 2026 · NCT07218055

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

  • University at Buffalo, Buffalo
RecruitingObservational study
18 Months – 11 Years · All sexes · Updated Jul 6, 2026 · NCT07048574

Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)

  • NYU Langone Health, New York
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Jun 29, 2026 · NCT06901687

Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

  • NYU Langone Health, New York
Recruiting
Ages 24 to 65 · All sexes · Updated Jun 29, 2026 · NCT07111390

Virtual Reality for Pain Management in Burn Patients

  • Weill Cornell Medicine, New York
Recruiting
Ages 8 and older · All sexes · Updated Jun 17, 2026 · NCT04685486

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

  • Dent Neurological Institute, Amherst
  • Trinity Medical, Lewiston
  • Icahn School of Medicine at Mount Sinai, New York
  • and 1 more
Recruiting
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03887715

WeCare: A System of Care for Black Youth

  • Kings County Hospital, New York
RecruitingHealthy volunteers welcome
Ages 12 to 19 · All sexes · Updated Jun 10, 2026 · NCT05654207

tDCS: Sleep to Mood in Depression (S2M-D)

  • NYU Langone Health, New York
Recruiting
Ages 18 to 65 · All sexes · Updated Jun 8, 2026 · NCT07572526

Personalized Mobile Cognitive Behavioral Therapy Application

  • Weill Cornell Medical College, New York
Recruiting
Ages 18 to 25 · All sexes · Updated May 22, 2026 · NCT05699525

Mobile CBT for Middle Aged and Older Adults

  • Weill Cornell Medicine, New York
Recruiting
Ages 40 and older · All sexes · Updated May 22, 2026 · NCT05754151

Harlem Strong Mental Health Coalition

  • CUNY Graduate School of Public Health and Health Policy, New York
  • Harlem Congregation for Community Improvement, New York
RecruitingHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated May 20, 2026 · NCT05833555

Prevention of Psychological Health Problems Via Integrated Operational Support

  • New York University, New York
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT06981598

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.