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Depression clinical trials recruiting in the U.S.

421 studies for Depression are recruiting participants at sites across the United States.

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

Cities with the most studies

• Boston, MA51 studies
• New York City, NY46 studies
• Philadelphia, PA24 studies
• Chicago, IL23 studies
• Pittsburgh, PA22 studies
• Atlanta, GA22 studies
• San Diego, CA21 studies
• Charleston, SC19 studies
• Houston, TX18 studies
• Orlando, FL17 studies
• Los Angeles, CA17 studies
• Miami, FL16 studies
• Durham, NC15 studies
• Washington, DC15 studies
• San Francisco, CA15 studies
• St. Louis, MO15 studies
• Austin, TX15 studies
• Baltimore, MD14 studies
• Tampa, FL14 studies
• Aurora, CO13 studies
• Dallas, TX13 studies
• Columbus, OH11 studies
• Mountain View, CA10 studies
• Jacksonville, FL10 studies
• Seattle, WA10 studies
• Minneapolis, MN10 studies
• Little Rock, AR10 studies
• New Haven, CT9 studies
• Orange, CA9 studies
• Ann Arbor, MI9 studies
• Germantown, MD8 studies
• Birmingham, AL8 studies
• Cincinnati, OH8 studies
• Madison, WI8 studies
• Cambridge, MA7 studies
• Grand Prairie, TX7 studies
• Everett, WA7 studies
• The Bronx, NY7 studies
• Las Vegas, NV7 studies
• New Orleans, LA7 studies

By state

• Alabama14 studies
• Arizona12 studies
• Arkansas10 studies
• California69 studies
• Colorado20 studies
• Connecticut15 studies
• District of Columbia4 studies
• Florida45 studies
• Georgia26 studies
• Idaho3 studies
• Illinois27 studies
• Indiana6 studies
• Iowa5 studies
• Kansas6 studies
• Louisiana10 studies
• Maryland29 studies
• Massachusetts64 studies
• Michigan17 studies
• Minnesota15 studies
• Mississippi3 studies
• Missouri20 studies
• Montana3 studies
• Nebraska3 studies
• Nevada7 studies
• New Hampshire4 studies
• New Jersey12 studies
• New Mexico5 studies
• New York61 studies
• North Carolina26 studies
• Ohio26 studies
• Oklahoma12 studies
• Oregon8 studies
• Pennsylvania48 studies
• Rhode Island5 studies
• South Carolina20 studies
• Tennessee12 studies
• Texas51 studies
• Utah10 studies
• Virginia12 studies
• Washington20 studies
• Wisconsin11 studies

Recently updated studies

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.