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Depression clinical trials recruiting in the U.S.

416 studies for Depression are recruiting participants at sites across the United States.

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

Cities with the most studies

• Boston, MA50 studies
• New York City, NY44 studies
• Chicago, IL26 studies
• Atlanta, GA22 studies
• Pittsburgh, PA22 studies
• Philadelphia, PA21 studies
• Charleston, SC18 studies
• San Diego, CA18 studies
• Houston, TX18 studies
• Los Angeles, CA17 studies
• Washington, DC16 studies
• San Francisco, CA15 studies
• Orlando, FL15 studies
• Miami, FL15 studies
• Durham, NC14 studies
• Aurora, CO13 studies
• Dallas, TX12 studies
• St. Louis, MO11 studies
• Austin, TX11 studies
• Baltimore, MD11 studies
• Tampa, FL11 studies
• Seattle, WA10 studies
• New Haven, CT10 studies
• Columbus, OH10 studies
• Minneapolis, MN10 studies
• Birmingham, AL9 studies
• Jacksonville, FL9 studies
• Cambridge, MA9 studies
• Mountain View, CA9 studies
• Cincinnati, OH8 studies
• Nashville, TN8 studies
• Ann Arbor, MI8 studies
• Orange, CA8 studies
• The Bronx, NY8 studies
• New Orleans, LA7 studies
• Cleveland, OH7 studies
• Hollywood, FL7 studies
• Little Rock, AR7 studies
• Grand Prairie, TX7 studies
• Portland, OR6 studies

By state

• Alabama14 studies
• Arizona10 studies
• Arkansas7 studies
• California67 studies
• Colorado18 studies
• Connecticut15 studies
• District of Columbia4 studies
• Florida41 studies
• Georgia26 studies
• Idaho4 studies
• Illinois29 studies
• Indiana6 studies
• Iowa6 studies
• Kansas6 studies
• Louisiana8 studies
• Maryland27 studies
• Massachusetts63 studies
• Michigan17 studies
• Minnesota14 studies
• Mississippi3 studies
• Missouri14 studies
• Montana3 studies
• Nebraska4 studies
• Nevada7 studies
• New Hampshire5 studies
• New Jersey9 studies
• New Mexico4 studies
• New York60 studies
• North Carolina23 studies
• Ohio23 studies
• Oklahoma6 studies
• Oregon8 studies
• Pennsylvania46 studies
• Rhode Island4 studies
• South Carolina19 studies
• Tennessee13 studies
• Texas46 studies
• Utah10 studies
• Virginia10 studies
• Washington18 studies
• Wisconsin10 studies

Recently updated studies

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.