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Esophageal Cancer clinical trials recruiting in the U.S.

110 studies for Esophageal Cancer are recruiting participants at sites across the United States.

Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.

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Recently updated studies

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07578571

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07603375

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07519655

DESTINY-PANTUMOUR04

RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06123338

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379

Pan-tumor MRD Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404

sFOLFOXIRI in Advanced Gastroesophageal Cancer, (SAGE)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05332002

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

RecruitingObservational study
Ages 2 to 120 · All sexes · Updated Sep 23, 2026 · NCT00242723

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

Prehabilitation in High-risk Oncologic Surgery

Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07638410

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07217704

Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07685938

HEARTS Trial for Thoracic Cancers

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07132918

A Study of 2141-V11 in People With Esophageal, Gastric, or Gastroesophageal Junction Adenocarcinoma

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07818018

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

Resilience and Equity in Aging, Cancer, and Health (REACH)

Recruiting
Ages 65 and older · All sexes · Updated Sep 10, 2026 · NCT04674267

SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07812805

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.