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Esophageal Cancer clinical trials recruiting in the U.S.

110 studies for Esophageal Cancer are recruiting participants at sites across the United States.

Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.

Cities with the most studies

By state

Recently updated studies

Hypoxia Imaging for Esophageal Cancer to Guide Personalized Radiation Therapy

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT04846309

18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06414902

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Recruiting
Ages 18 to 99 · All sexes · Updated Nov 12, 2026 · NCT04907643

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
Ages 45 to 75 · All sexes · Updated Nov 6, 2026 · NCT06995898

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07090499

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07519655

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06465069

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT05366881

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07603375

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069

Novel Bipolar Radiofrequency Ablation Knife in Esophageal Lesions

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06476678

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07283939

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

RecruitingPhase 1/2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT03556228

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07213791

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07114601

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07059884

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06695845

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07578571

A Study to Learn About the Study Medicine Called PF-08098488 in People With Advanced Solid Tumors.

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07903415

Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07124351

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT03526835

A Study of MGC030 in Participants With Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07822399

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.