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Esophageal Cancer clinical trials recruiting in the U.S.
110 studies for Esophageal Cancer are recruiting participants at sites across the United States.
Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.
Cities with the most studies
- Houston, TX37 studies
- New York City, NY24 studies
- Boston, MA23 studies
- Nashville, TN19 studies
- St. Louis, MO17 studies
- Los Angeles, CA16 studies
- Grand Rapids, MI15 studies
- Pittsburgh, PA15 studies
- Baldwin Park, CA14 studies
- San Antonio, TX13 studies
- Chicago, IL13 studies
- Dallas, TX12 studies
- Arlington, VA12 studies
- Philadelphia, PA12 studies
- Portland, OR10 studies
- Durham, NC10 studies
- San Diego, CA10 studies
- Cleveland, OH10 studies
- Denver, CO9 studies
- Rochester, MN9 studies
- Washington, DC9 studies
- Orlando, FL9 studies
- Atlanta, GA8 studies
- Indianapolis, IN8 studies
- Tampa, FL8 studies
- Queens, NY8 studies
- Edison, NJ8 studies
- Birmingham, AL8 studies
- Kansas City, MO8 studies
- Milwaukee, WI8 studies
- Detroit, MI8 studies
- Mountain View, CA7 studies
- Minneapolis, MN7 studies
- Columbus, OH7 studies
- Seattle, WA7 studies
- Aurora, CO7 studies
- Baltimore, MD7 studies
- Salt Lake City, UT6 studies
- Orange, CA6 studies
- New Haven, CT6 studies
By state
- Alabama8 studies
- Alaska4 studies
- Arizona11 studies
- Arkansas6 studies
- California41 studies
- Colorado19 studies
- Connecticut9 studies
- Delaware3 studies
- District of Columbia4 studies
- Florida32 studies
- Georgia9 studies
- Idaho3 studies
- Illinois16 studies
- Indiana11 studies
- Iowa6 studies
- Kansas9 studies
- Kentucky8 studies
- Louisiana5 studies
- Maine3 studies
- Maryland13 studies
- Massachusetts25 studies
- Michigan21 studies
- Minnesota17 studies
- Missouri20 studies
- Montana4 studies
- Nebraska7 studies
- New Jersey9 studies
- New Mexico6 studies
- New York31 studies
- North Carolina16 studies
- North Dakota4 studies
- Ohio20 studies
- Oklahoma8 studies
- Oregon11 studies
- Pennsylvania28 studies
- Rhode Island3 studies
- South Carolina7 studies
- South Dakota4 studies
- Tennessee21 studies
- Texas47 studies
- Utah7 studies
- Virginia18 studies
- Washington11 studies
- West Virginia3 studies
- Wisconsin14 studies
Recently updated studies
Hypoxia Imaging for Esophageal Cancer to Guide Personalized Radiation Therapy
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT04846309Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT0646994418F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06414902Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Recruiting
Ages 18 to 99 · All sexes · Updated Nov 12, 2026 · NCT04907643The Vanguard Study: Testing a New Way to Screen for Cancer
RecruitingHealthy volunteers welcome
Ages 45 to 75 · All sexes · Updated Nov 6, 2026 · NCT06995898A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07090499Phase 1 Study of PF-08046033 in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07519655A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06465069cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT05366881Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07603375Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069Novel Bipolar Radiofrequency Ablation Knife in Esophageal Lesions
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06476678Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07283939VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
RecruitingPhase 1/2
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT03556228A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07213791A Study of LY4257496 in Participants With Cancer (OMNIRAY)
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07114601Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07059884A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06760819A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06695845A Phase 1 Study of IM-1617 in Participants With Advanced Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07578571A Study to Learn About the Study Medicine Called PF-08098488 in People With Advanced Solid Tumors.
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07903415Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers
RecruitingObservational study
Ages 21 to 90 · All sexes · Updated Nov 3, 2026 · NCT00900419Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07124351A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT03526835A Study of MGC030 in Participants With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07822399From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.