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Esophageal Cancer clinical trials recruiting in the U.S.
110 studies for Esophageal Cancer are recruiting participants at sites across the United States.
Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.
Cities with the most studies
- Houston, TX36 studies
- Boston, MA23 studies
- New York City, NY22 studies
- Nashville, TN19 studies
- St. Louis, MO17 studies
- Los Angeles, CA15 studies
- Pittsburgh, PA15 studies
- Baldwin Park, CA14 studies
- Grand Rapids, MI14 studies
- Philadelphia, PA13 studies
- San Antonio, TX12 studies
- Dallas, TX11 studies
- Arlington, VA11 studies
- Chicago, IL11 studies
- Rochester, MN11 studies
- Cleveland, OH10 studies
- San Diego, CA10 studies
- Portland, OR10 studies
- Durham, NC10 studies
- Washington, DC9 studies
- Detroit, MI9 studies
- Denver, CO9 studies
- Orlando, FL8 studies
- Atlanta, GA8 studies
- Birmingham, AL8 studies
- Edison, NJ8 studies
- Indianapolis, IN8 studies
- Tampa, FL8 studies
- Minneapolis, MN8 studies
- Milwaukee, WI8 studies
- Salt Lake City, UT7 studies
- Columbus, OH7 studies
- Toledo, OH7 studies
- Mountain View, CA7 studies
- Aurora, CO7 studies
- Santa Monica, CA7 studies
- Seattle, WA7 studies
- Baltimore, MD7 studies
- Kansas City, MO7 studies
- Oklahoma City, OK6 studies
By state
- Alabama8 studies
- Alaska4 studies
- Arizona11 studies
- Arkansas6 studies
- California41 studies
- Colorado19 studies
- Connecticut9 studies
- Delaware3 studies
- District of Columbia4 studies
- Florida33 studies
- Georgia10 studies
- Idaho3 studies
- Illinois15 studies
- Indiana12 studies
- Iowa6 studies
- Kansas8 studies
- Kentucky8 studies
- Louisiana4 studies
- Maine3 studies
- Maryland13 studies
- Massachusetts25 studies
- Michigan22 studies
- Minnesota19 studies
- Missouri20 studies
- Montana4 studies
- Nebraska7 studies
- New Jersey9 studies
- New Mexico6 studies
- New York28 studies
- North Carolina16 studies
- North Dakota4 studies
- Ohio22 studies
- Oklahoma8 studies
- Oregon11 studies
- Pennsylvania29 studies
- Rhode Island3 studies
- South Carolina7 studies
- South Dakota4 studies
- Tennessee21 studies
- Texas46 studies
- Utah8 studies
- Virginia16 studies
- Washington11 studies
- West Virginia3 studies
- Wisconsin16 studies
Recently updated studies
A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07814248A Phase 1 Study of IM-1617 in Participants With Advanced Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07578571Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07603375Phase 1 Study of PF-08046033 in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07519655DESTINY-PANTUMOUR04
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06123338Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379Pan-tumor MRD Study
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404sFOLFOXIRI in Advanced Gastroesophageal Cancer, (SAGE)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05332002Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
RecruitingObservational study
Ages 2 to 120 · All sexes · Updated Sep 23, 2026 · NCT00242723Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791A Study of LY4257496 in Participants With Cancer (OMNIRAY)
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601Prehabilitation in High-risk Oncologic Surgery
Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07638410Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07217704Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07685938EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Recruiting
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06263088HEARTS Trial for Thoracic Cancers
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07132918A Study of 2141-V11 in People With Esophageal, Gastric, or Gastroesophageal Junction Adenocarcinoma
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07818018ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898Resilience and Equity in Aging, Cancer, and Health (REACH)
Recruiting
Ages 65 and older · All sexes · Updated Sep 10, 2026 · NCT04674267SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07812805From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.