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Esophageal Squamous Cell Carcinoma clinical trials recruiting in the U.S.
35 studies for Esophageal Squamous Cell Carcinoma are recruiting participants at sites across the United States.
Cities with the most studies
- Arlington, VA14 studies
- Nashville, TN12 studies
- Houston, TX11 studies
- Los Angeles, CA11 studies
- Baldwin Park, CA8 studies
- West Valley City, UT7 studies
- San Antonio, TX7 studies
- New York City, NY7 studies
- Queens, NY6 studies
- Dallas, TX6 studies
- Detroit, MI5 studies
- Fort Worth, TX5 studies
- Santa Monica, CA5 studies
- Boston, MA5 studies
- Orlando, FL5 studies
- Portland, OR4 studies
- Grand Rapids, MI4 studies
- Austin, TX4 studies
- Cleveland, OH4 studies
- St. Louis, MO4 studies
- Pittsburgh, PA4 studies
- Irvine, CA4 studies
- Atlanta, GA4 studies
- Spokane, WA3 studies
- Irving, TX3 studies
- Bridgeport, CT3 studies
- Philadelphia, PA3 studies
- Orange, CA3 studies
- Durham, NC3 studies
- Seattle, WA3 studies
- Rochester, MN3 studies
- Fullerton, CA3 studies
- Las Vegas, NV3 studies
- Chicago, IL3 studies
- Omaha, NE3 studies
- Coral Springs, FL3 studies
- San Francisco, CA3 studies
- New Haven, CT3 studies
By state
- Arizona6 studies
- California23 studies
- Connecticut4 studies
- Florida11 studies
- Georgia4 studies
- Illinois5 studies
- Massachusetts5 studies
- Michigan10 studies
- Minnesota5 studies
- Missouri5 studies
- Nebraska3 studies
- Nevada3 studies
- New Jersey4 studies
- New York14 studies
- North Carolina4 studies
- Ohio7 studies
- Oregon4 studies
- Pennsylvania8 studies
- Tennessee12 studies
- Texas19 studies
- Utah7 studies
- Virginia14 studies
- Washington7 studies
Recently updated studies
A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07277413A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07229313Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379A Study of ASP388B Given by Itself and With Standard Therapies in Participants With Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07730021A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07405151Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06780111A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07217171Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06535607A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07090499A Study of IDP-001 in Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07602842A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05319730A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT07554521Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06084481Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers
Recruiting
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT04221893A Study of MGC026 in Participants With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06242470A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT06644781A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06657144Integrated Cf-miRNA and Exosomal miRNA Signature for Early Detection of Esophageal Squamous Cell Carcinoma
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT07266363A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT07224750A Study of Sigvotatug Vedotin in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT06747585Study of XB010 in Subjects With Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06545331A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT07503808From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.