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Fatigue clinical trials recruiting in the U.S.

62 studies for Fatigue are recruiting participants at sites across the United States.

Are you tired? Find out about some of the common and uncommon causes of fatigue and how to help yourself.

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Recently updated studies

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Idiopathic Hypersomnia (IH)

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 13, 2026 ยท NCT07500090

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 13, 2026 ยท NCT07675135

Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus

Recruiting
Ages 12 to 22 ยท All sexes ยท Updated Nov 13, 2026 ยท NCT06232304

Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers

RecruitingPhase 2/3
Ages 18 and older ยท All sexes ยท Updated Oct 19, 2026 ยท NCT06085716

Mind-Body Group Interventions for Psychological Distress in Young Breast Cancer Survivors

Recruiting
Ages 18 to 50 ยท Women ยท Updated Oct 16, 2026 ยท NCT07501637

Characterizing Perceived Physical Fatigability in Nusinersen-treated SMA

RecruitingObservational study
Ages 12 and older ยท All sexes ยท Updated Oct 14, 2026 ยท NCT06955897

Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients

RecruitingPhase 2
Ages 6 and older ยท Men ยท Updated Oct 8, 2026 ยท NCT07766980

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

RecruitingPhase 3
Ages 18 to 70 ยท All sexes ยท Updated Oct 7, 2026 ยท NCT07455383

The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

Recruiting
Ages 18 and older ยท All sexes ยท Updated Oct 6, 2026 ยท NCT07504120

The Impact of Qualia Vitamin C+ on Individuals With Suboptimal and Adequate Vitamin C Levels

RecruitingHealthy volunteers welcome
Ages 25 to 75 ยท All sexes ยท Updated Oct 5, 2026 ยท NCT07652346

Brain Stimulation Effects on Post-Stroke Fatigue and Aphasia

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 30, 2026 ยท NCT07151677

Cardiac Output and Fatigue in Friedreich's Ataxia

Recruiting
All ages ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07444333

Natural History Study of Mitochondrial Myopathy

RecruitingObservational studyHealthy volunteers welcome
Ages 0 to 100 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT05250375

Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue

RecruitingPhase 2
Ages 34 to 80 ยท All sexes ยท Updated Sep 14, 2026 ยท NCT05584124

C-Protein in Fatigue and Aging

RecruitingHealthy volunteers welcome
Ages 18 to 80 ยท All sexes ยท Updated Sep 9, 2026 ยท NCT05926219

Fight Fatigue: A Progressive Muscle Relaxation and Walking Intervention to Reduce Fatigue in Adults With ESKD

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 2, 2026 ยท NCT07014111

Near-Infrared Spectroscopy, Acute Taurine Supplementation, and Isolated Muscular Endurance and Fatigue Resistance in Young Healthy Adults

RecruitingHealthy volunteers welcome
Ages 18 to 40 ยท All sexes ยท Updated Aug 26, 2026 ยท NCT07654946

Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients

Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 24, 2026 ยท NCT06978127

Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

Recruiting
Ages 18 to 100 ยท All sexes ยท Updated Aug 10, 2026 ยท NCT07180537

Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jul 24, 2026 ยท NCT06634381

Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study

Recruiting
Ages 18 and older ยท All sexes ยท Updated Jul 10, 2026 ยท NCT07581080

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.