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The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

Does Remotely Delivered Pilates Influence Physical and Psychological Outcomes in Individuals With Multiple Sclerosis?

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age 18 years or older
* Self-reported diagnosis of multiple sclerosis by a neurologist
* Relapse-free for the past 30 days before screening
* Able to speak and read English as the primary language
* Access to the internet and e-mail,
* Ability to use Zoom, and willingness to complete testing sessions and questionnaires
* Ambulatory without an assistive device (for example, cane)
* Low to moderate disability, defined as a score of 0-4 on the Patient-Determined Disease Steps (PDDS)
* Insufficiently active, defined as a score \< 14 on the Godin Leisure-Time Exercise Questionnaire-Health Contribution Score (GLTEQ-HCS)
* Adequate visual ability and literacy to read materials printed in 14-point font
* Currently treated with a disease-modifying therapy

Exclusion Criteria:

* Pregnant
* Elevated risk for strenuous or maximal exercise, defined as more than one "Yes" response on the Physical Activity Readiness Questionnaire (PAR-Q) during screening

About the study

Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS.

Objective 2: To examine the impact of a 16-week remotely delivered Pilates intervention on depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.

Aim Aim 1: To assess whether the 16-week remotely delivered Pilates intervention significantly improves walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS Aim 2: To investigate whether the 16-week remotely delivered Pilates intervention significantly improves depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.

Hypothesis Hypothesis 1: The 16-week remotely delivered Pilates intervention will significantly improve walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS.

Hypothesis 2: Participants receiving the 16-week remotely delivered Pilates intervention will demonstrate significantly greater improvements in depression \& anxiety, cognitive function, and QOL compared to a waitlist control group in individuals with MS.

What is being tested

• Pilates (behavioral)

Sponsor: University of Illinois Chicago · Participants: 50 · Started: Nov 1, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07504120

Locations in the U.S.

Conditions

• Multiple Sclerosis
• Depression
• Fatigue
• Pain

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.