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Gastrointestinal Cancers clinical trials recruiting in the U.S.

72 studies for Gastrointestinal Cancers are recruiting participants at sites across the United States.

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Recently updated studies

Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07529808

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07218926

DESTINY-PANTUMOUR04

RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal, Gynecological, Breast, or Lung Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06855524

A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06663319

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06445062

Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05274048

GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

RecruitingEarly phase 1
Ages 18 to 99 · All sexes · Updated Sep 18, 2026 · NCT07627191

SURGE: Supporting Utility and Representation in Genomics-based Cancer Trial Enrollment (Intervention)

Recruiting
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05375643

Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06633224

Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT01313442

Resilience and Equity in Aging, Cancer, and Health (REACH)

Recruiting
Ages 65 and older · All sexes · Updated Sep 10, 2026 · NCT04674267

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT04899908

Study to Assess the Efficacy and Safety of Rina-S in Participants With Advanced Gastrointestinal (GI) Cancers

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07539311

Personalized Health Self-Management Training for Colorectal Cancer Survivors

Recruiting
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT05984589

The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT04700527

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07283939

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

Recruiting
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05837767

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 28, 2026 · NCT06596694

A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07544589

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06582017

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.