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Germ Cell and Embryonal Cancer clinical trials recruiting in the U.S.

21 studies for Germ Cell and Embryonal Cancer are recruiting participants at sites across the United States.

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Recently updated studies

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

RecruitingPhase 1
36 Months – 22 Years · All sexes · Updated Sep 4, 2026 · NCT03911388

Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours

RecruitingPhase 3
Ages 11 to 50 · All sexes · Updated Sep 1, 2026 · NCT02582697

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

RecruitingPhase 1
Ages 15 and older · All sexes · Updated Aug 25, 2026 · NCT06276491

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

RecruitingPhase 1
12 Months – 25 Years · All sexes · Updated Aug 3, 2026 · NCT04099797

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07628634

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

RecruitingPhase 1/2
Ages 4 to 39 · All sexes · Updated Jul 20, 2026 · NCT05278208

Patient Reported Experiences With Sparing External Oblique Fascia Vs Standard Inguinal Orchiectomy

Recruiting
Ages 18 and older · Men · Updated Jul 10, 2026 · NCT06828185

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

RecruitingPhase 1
Up to age 21 · All sexes · Updated May 19, 2026 · NCT04897321

Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT04804007

A Study of ZW251 in Participants With Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated May 7, 2026 · NCT07164313

Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

RecruitingPhase 1
Ages 1 to 30 · All sexes · Updated Apr 15, 2026 · NCT04308330

Germ Cell Tumor and Testicular Tumor DNA Registry

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Feb 4, 2026 · NCT02099734

Maintenance Zanzalintinib With Etoposide After HDCT in GCT

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT06937866

Molecular Epidemiology of Pediatric Germ Cell Tumors

RecruitingObservational study
All ages · All sexes · Updated Oct 24, 2025 · NCT05564026

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.